侯廣濤
[摘要] 目的 探究與分析黃芪結(jié)合標(biāo)準(zhǔn)三聯(lián)療法根除幽門(mén)螺桿菌的臨床效果。 方法 選取該院自2012年10月—2014年10月收治的Hp感染陽(yáng)性的的胃炎或消化性潰瘍患者240例,采取隨機(jī)數(shù)字表法分為A組、B組、C組、D組,每組各60例。A組給予泮托拉唑+阿莫西林+克拉霉素治療。B組、C組、D組在A組基礎(chǔ)上分別給予黃芪顆粒1g、2g、3g治療。對(duì)比四組HP根除率及不良反應(yīng)。 結(jié)果 B組較A組相比,HP根除率明顯提升(P<0.05),C組較A組相比,HP根除率明顯提升(P<0.05),D組較A組相比,HP根除率明顯提升(P<0.05),其中C組HP根除率提高程度明顯高于B組,D組HP根除率提高程度明顯高于C組。四組患者不良反應(yīng)的發(fā)生率比較無(wú)明顯差異(P>0.05)。 結(jié)論 黃芪結(jié)合標(biāo)準(zhǔn)三聯(lián)療法可達(dá)到更好的殺滅幽門(mén)螺桿菌的效果,不良反應(yīng)較少,安全性高,值得推廣。
[關(guān)鍵詞] 黃芪;三聯(lián)療法;幽門(mén)螺桿菌;根除
[中圖分類(lèi)號(hào)] R725 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-0742(2015)02(a)-0106-02
Astragalus membranaceus combined with standard triple therapy the eradication of helicobacter pylori in clinical research
HOU Guangtao
Qingdao university medical college,shandong 262500,China
[Abstract] objective to explore and analyze the root of remembranous milk vetch combined with standard triple therapy clinical effect of helicobacter pylori eradication. Methods select our hospital from October 2012 to October 2012 Hp infection were positive in 240 cases of patients with gastritis and peptic ulcer, take A random number table method is divided into group A and group B, C, D group, each group of 60 cases each. A group was given diazepam tora azole, amoxicillin and clarithromycin treatment. Group B, C, D group on the basis of group A were given astragalus particles 1 g, 2 g, 3 g, treatment. Four groups of HP eradicate rate and adverse reactions. Results compared with group B than in group A, HP eradicate rate improved significantly (P < 0.05), compared with group C compared with group A, HP eradicate rate improved significantly (P < 0.05), group D is compared to group A, HP eradicate rate improved significantly(P < 0.05), including HP eradicate rate of group C was significantly higher than that of group B, group D HP eradicate rate increase was significantly higher than that of group C. Four groups of patients the incidence of adverse reactions was no significant difference(P > 0.05). Conclusion astragalus membranaceus combined with standard triple therapy can achieve better kill the effect of helicobacter pylori, less adverse reaction, high safety, is worth promoting.
[Key words] Astragalus; Triple therapy; Helicobacter pylori; Eradicate
目前已有研究報(bào)道指出,幽門(mén)螺桿菌(HP)感染是上胃腸道疾病疾病中慢性胃炎、消化性潰瘍、胃癌等疾病的主要致病原因,同時(shí)還涉及到心腦血管、血液、免疫等諸多胃腸道外多系統(tǒng)疾病,為患者的健康造成較大影響[1]。但近年來(lái),隨著Hp耐藥性不斷增加,標(biāo)準(zhǔn)療法的根除率隨之降低。據(jù)我國(guó)第四次全國(guó)幽門(mén)螺桿菌感染處理共識(shí)報(bào)告中指出可以采用中藥或在西藥基礎(chǔ)上聯(lián)合中藥治療,作為根除幽門(mén)螺桿菌感染的一類(lèi)新型手段,以從根本上提高Hp的根除率[2]。該次研究中,將黃芪結(jié)合標(biāo)準(zhǔn)三聯(lián)療法應(yīng)用于根除幽門(mén)螺桿菌的治療過(guò)程中,取得了顯著的臨床療效,現(xiàn)報(bào)道如下。
1 資料與方法
1.1 一般資料endprint