血脂水平與子宮內(nèi)膜異位癥關(guān)系的Meta分析

姬笑影 任琛琛 楊立 朱遠(yuǎn)航 李飛燕 楊欣 鄭婭婷

[摘要] 目的 探討人的血脂水平與子宮內(nèi)膜異位癥之間的關(guān)系。 方法 在線檢索Pubmed、Web of Science、Scopus、中國(guó)知網(wǎng)、萬(wàn)方、維普數(shù)據(jù)庫(kù)，收集人血脂水平與子宮內(nèi)膜異位癥相關(guān)性的研究，檢索時(shí)間為建庫(kù)至2020年12月。對(duì)其進(jìn)行質(zhì)量評(píng)估和數(shù)據(jù)提取后，應(yīng)用RevMan5.3進(jìn)行Meta分析。 結(jié)果 納入文獻(xiàn)7篇，共包括755例子宮內(nèi)膜異位癥患者，734例對(duì)照者。Meta分析結(jié)果：剔除異質(zhì)性較高文獻(xiàn)后，子宮內(nèi)膜異位癥患者HDL-c高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義[SMD=0.36，95%CI（0.24，0.49），P<0.00001，I2=46%]?？偰懝檀糩SMD=0.27，95%CI（-0.10，0.64），P=0.15，I2=91%]、低密度脂蛋白膽固醇[SMD=0.22，95%CI（-0.33，0.77），P=0.44，I2=94%]及三酰甘油[SMD=0.14，95%CI（-0.24，0.53），P=0.46，I2=92%]與子宮內(nèi)膜異位癥發(fā)病無(wú)相關(guān)性，且因異質(zhì)性較大，行亞組分析發(fā)現(xiàn)納入文獻(xiàn)的地域、年齡、樣本量均可能為異質(zhì)性來(lái)源而影響結(jié)果。 結(jié)論 血脂水平可能與子宮內(nèi)膜異位癥相關(guān)，較高的高密度脂蛋白膽固醇水平可能是子宮內(nèi)膜異位癥發(fā)生的危險(xiǎn)因素，總膽固醇、低密度脂蛋白膽固醇及三酰甘油水平與子宮內(nèi)膜異位癥的關(guān)系尚需進(jìn)一步證實(shí)。

[關(guān)鍵詞] 子宮內(nèi)膜異位癥;血脂;膽固醇;三酰甘油;Meta分析

[中圖分類號(hào)] R711.71? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1673-9701（2021）25-0004-06

Meta-analysis of relationship between blood lipid levels and endometriosis

JI Xiaoying? ?REN Chenchen? ?YANG Li? ?ZHU Yuanhang? ?LI Feiyan? ?YANG Xin? ?ZHENG Yating

Department of Gynecology， the Third Affiliated Hospital of Zhengzhou University， Zhengzhou? ?450052， China

[Abstract] Objective To explore the relationship between the level of blood lipid and endometriosis in human. Methods Online retrievals of PubMed， Web of Science， Scopus， CNKI， Wanfang， and VIP databases were conducted to collect the studies on the correlation between the human blood lipid level and endometriosis. The retrieval period was from the establishment of the database to December 2020. After quality assessment and data extraction， Meta-analysis was performed by using RevMan5.3. Results Seven studies were included， including 755 patients with endometriosis and 734 controls. Results of Meta-analysis： HDL-c was higher in endometriosis patients than that in patients in the control group after literatures with higher heterogeneity were excluded， and the difference was statistically significant [SMD=0.36， 95%CI （0.24， 0.49）， P<0.00001， I2=46%]. No correlations with the incidence of endometriosis were observed in total cholesterol [SMD=0.27， 95%CI （-0.10， 0.64）， P=0.15， I2=91%]， low density lipoprotein cholesterol [SMD=0.22， 95%CI （-0.33， 0.77）， P=0.44， I2=94%] and triglycerides [SMD=0.14， 95%CI （-0.24， 0.53）， P=0.46， I2=92%]， which were caused by great heterogeneity. The region， age and sample size of the included literatures were all likely to influence the results due to their heterogeneity， which was found by subgroup analysis. Conclusion The blood lipid level may be related to endometriosis， and high HDL cholesterol level may be a risk factor for the occurrence of endometriosis. The relationship between total cholesterol， low density lipoprotein cholesterol and triglyceride levels and endometriosis needs to be further confirmed.