胡顯潔 孫燕 侯存
[摘要] 目的 探討綜合療法治療內分泌失調性骨質疏松癥的臨床療效。 方法 便利選擇該院2016年6月—2017年9月收治的內分泌失調性骨質疏松癥患者132例,以便利抽樣法分為參照組和治療組各66例,參照組采取常規(guī)療法,治療組采取綜合治療,對比兩組患者臨床療效。 結果 治療組總有效率98.48%高于參照組87.88%,NRS疼痛評分(2.72±1.38)分、骨折發(fā)生率1.52%低于參照組[NRS疼痛評分(5.24±1.66)分、骨折發(fā)生率10.61%],且股骨頸(817.25±59.75)mg/cm3、Wards三角區(qū)(649.01±52.33)mg/cm3、大轉子(733.45±59.55)mg/cm3骨密度值均高于參照組[股骨頸(784.26±43.84)mg/cm3、Wards三角區(qū)(594.09±49.91)mg/cm3、大轉子(701.45±49.65)mg/cm3](P<0.05)。 結論 綜合療法治療內分泌失調性骨質疏松癥可有效改善患者骨密度,降低骨折風險,值得臨床應用。
[關鍵詞] 綜合治療;內分泌失調性骨質疏松;療效觀察
[中圖分類號] R5? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-0742(2019)05(a)-0079-03
[Abstract] Objective To investigate the clinical efficacy of comprehensive therapy in the treatment of endocrine dysregulated osteoporosis. Methods A total of 132 patients with endocrine dysregulated osteoporosis admitted to our hospital from June 2016 to September 2017 were convenient selected and enrolled. The patients were divided into a reference group and a treatment group by 66 cases. The reference group took conventional therapy and the treatment group took Comprehensive treatment, comparing the clinical efficacy of the two groups of patients. Results The total effective rate of the treatment group was 98.48% higher than that of the reference group(87.88%), the NRS pain score (2.72±1.38) points, and the fracture incidence rate was 1.52% lower than the reference group [NRS pain score (5.24±1.66)points, fracture incidence rate 10.61%]. The femoral neck (817.25±59.75) mg/cm3, Wards triangle (649.01±52.33) mg/cm3, and greater trochanter (733.45±59.55) mg/cm3 bone mineral density were higher than the reference group [femoral neck (784.26±43.84) mg/cm3, Wards triangle (594.09±49.91) mg/cm3, greater trochanter (701.45±49.65) mg/cm3](P<0.05). Conclusion Comprehensive therapy for endocrine disorders of osteoporosis can effectively improve bone mineral density and reduce fracture risk, which is worthy of clinical application.
[Key words] Comprehensive treatment; Endocrine disorder osteoporosis; Therapeutic effect observation
內分泌失調性骨質疏松屬于臨床常見的骨代謝病癥,該病可進一步發(fā)展為全身性骨痛、駝背、身高縮短、呼吸障礙,隨著患者骨密度持續(xù)降低,發(fā)生脆性骨折的風險極高[1]。目前臨床多采取二磷酸鹽、降鈣素等藥物抑制破骨細胞活性,但僅能減少骨量丟失,無法重建已經(jīng)破壞的骨質,因此多種途徑綜合療法是目前治療內分泌失調性骨質疏松癥的臨床研究重點。該次研究基于以上論述,疼痛了綜合療法對內分泌失調性骨質疏松癥的效果,便利選擇該院2016年6月—2017年9月收治的內分泌失調性骨質疏松癥患者132例為研究樣本,現(xiàn)報道如下。
1? 資料與方法
1.1? 一般資料
便利選擇該院收治的內分泌失調性骨質疏松癥患者132例,以便利抽樣法分為參照組和治療組各66例,參照組男28例,女38例,年齡45~80歲,中位年齡(60.14±3.26)歲,病程2~8年,平均(4.27±1.33)年;治療組男29例,女37例,年齡46~79歲,中位年齡(60.11±3.19)歲,病程2~9年,平均(4.29±1.41)年。兩組患者基線資料對比差異無統(tǒng)計學意義(P>0.05),具有可比性。