• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    A new handheld fundus camera combined with visual artificial intelligence facilitates diabetic retinopathy screening

    2022-04-19 06:57:56ShangRuanYangLiuWeiTingHuHuiXunJiaShanShanWangMinLuSongMengXiShenDaWeiLuoTaoYeFengHuaWang
    關(guān)鍵詞:巴比倫儒教人臉

    INTRO D UCTION

    Diabetic retinopathy (DR) is the most common retinal vascular complication of diabetes mellitus (DM)and the leading cause of vision impairment and blindness among working-age adults. In Chinese adults, the overall standardized prevalence of diabetes using the WHO criteria is 11.2%, of which prediabetes accounts for 35.2%. DR is largely asymptomatic in the early stages, but neural retinal damage and clinically invisible microvascular changes progress during these early stages. It has therefore been widely accepted that periodic eye examinations should be conducted on all patients with DM to detect significant retinopathy andprovide prompt interventions when necessary, which is thought to be the most effective method to reduce potential DR-related visual disabilities.

    孔徑分布和截留相對分子量采用一系列的PEG截留率結(jié)果并通過Matlab軟件采用下述對數(shù)正態(tài)分布方程模擬計算得到[15]:

    Traditional tabletop-based, mydriatic retinal imaging modality is effective but is less available in underdeveloped rural areas. Handheld cameras are now emerging as a new low cost tool for DR screening, which can be conveniently used for patients who may not have access to ophthalmological care,with the potential of improving DR screening.

    In this study, we described a new portable Optomed Aurora fundus camera, and compared the image quality and DR detection with traditional tabletop fundus cameras. We also evaluated the feasibility of using a deep learning system(Phoebus, Shanghai, China) to detect different signs of DR to determine the possibility of combining the handheld fundus camera and AI technology during DR screening.

    However, it is difficult for physicians to perform routine dilated examinations on screened patients to detect non-symptomatic conditions owing to a presumption of patient unwillingness,lack of time, and unwarranted fears of harming patients with known glaucoma. Therefore, the quality of photography under non-mydriatic conditions is a critical evaluation index in DR screening. Compared to conventional cameras, the Aurora has a smaller minimum pupil size requirement (Table 2).For images taken during a non-mydriasis state, the Aurora handheld fundus camera had significantly better quality in centration, clarity, and visible range (1.47±0.46, 1.48±0.40, and 1.40±0.47, respectively) than conventional tabletop cameras(1.30±0.58, 1.28±0.19, and 1.18±0.61, respectively;<0.001).During the mydriasis state, the Optomed Aurora color images had imaging and grading characteristics similar to those of conventional tabletop cameras. Importantly, the advantage of not requiring pupillary dilation could provide the impetus for DR screening in underdeveloped regions.

    SUBJECTS AND METHODS

    The study was approved by the Shanghai General Hospital Institutional Review Board at Shanghai Jiao Tong University. Informed consent was obtained from all participants. The study was conducted in compliance with the Declaration of Helsinki, in accordance with the ICH-GCP(International Conference on Harmonization-Good Clinical Practice) guidelines (clinicaltrials.gov Registration Number:NCT03903042).

    Three parameters were assessed by the graders to investigate various aspects of image quality (Figure 1). For each parameter the quality score ranged from 2 (excellent) to 0 (ungradable). Images were considered to be excellent quality if the macula or optic disc was well-centered, showing clarity of the fundus vessels,with any retinopathy and the whole image being visible. If the macula or optic disc was partially centered and the fundus vessels and any retinopathy were recognizable and more than 80% of the image was visible, the images were defined as acceptable. If images were not centered, blurred without recognition of the retinal vessels or retinopathy features, or less than 80% of the image was visible, they were defined as ungradable.

    All photographs were randomized and presented to three masked and experienced ophthalmologists.The ophthalmologists separately evaluated their image quality and made diagnoses without information about the patients or the cameras used.

    This was a multi-centered, double-blinded,observational clinical study enrolling patients from three hospitals (Shanghai General Hospital, Shanghai, China; West Nanjing Road Community Health Center, Shanghai, China;and Zhaoqing Gaoyao People's Hospital, Guangdong, China).Individuals of ages 18y and older who had been diagnosed with DM were enrolled. Patients were excluded if the retina specialist could not visualize the fundus on examination or if they had previously undergone vitreoretinal surgery and/or laser photocoagulation. Classification of the severity stage of DR was determined using the International Clinical Diabetic Retinopathy Disease Severity Scale grading system developed by the American Academy of Ophthalmology (AAO)(Table 1).Four fundus photographs per eye were taken by a well-trained ophthalmic photographer: papilla- and maculacentered images using the tabletop and handheld Optomed Aurora fundus cameras (Optomed, Oulu, Finland), respectively,with or without pupil dilation with 1% tropicamide. The images obtained with the handheld fundus camera had a field of view of 50° and 5 mega-pixel resolution. Images from both kinds of cameras were acquired on the same day, which allowed for direct pathological identification and comparisons between these camera types. The characteristics of five types of fundus cameras are detailed in Table 2. The images were stored as JPEG (Joint Photographic Experts Group) files after removing patient names. Fundus images were transferred to the grading center, Shanghai General Hospital through the INSIGHT real-world patient registry platform www.chinadr.org.cn (Phoebus Medical, Shanghai, China), for remote digital retinal imaging grading.In this study, the images were uploaded to the deep learning system, Phoebus (Phoebus), and the detection of DR features was assessed. Phoebus provides a DR grade per image as well as visual representations of detected microaneurysms, retinal hemorrhages, hard exudations, and macular edemas. The DR output from Phoebus was further used to generate a prediction for the referral requirement.

    Overall, a total of 630 eyes of 315 DM patients were included in this study. The patients were on average 65.5±11.1y of age, and 53.7% were female (=169).The median duration of diabetes was 10y (3-15y), with more than one-third of the patients diagnosed with diabetes for less than 5y, and only 20 (6.3%) patients were diagnosed with diabetes for over 20y (Table 3).

    RESULTS

    Statistical analysis was performed using SPSS statistical software for Windows, version 20.0 (SPSS,Chicago, IL, USA). The data are presented as the mean±SD or median (IQR) for continuous variables and frequency (%)for categorical variables. Participant age was categorized by intervals of 10y, and age at diagnosis of diabetes was categorized by intervals of 5y. Sensitivity, specificity, and area under the receiver operator curve (AUC) with a 95% confidence interval(95%CI) were calculated to evaluate diagnostic accuracy.We used a receiver operating characteristic (ROC) curve to evaluate the classification ability of our built model.

    Of the 630 eyes examined, 242 eyes (38.4%)were photographed in the non-dilated state, while the remaining 388 eyes were dilated. The mean scores of the nonmydriasis image quality regarding image centration, sharpness,and visible range for the handheld fundus camera were 1.47,1.48, and 1.40, separately, resulting in a significant advantage over the conventional tabletop cameras (1.30, 1.28, 1.18,separately,<0.001). However, regarding the image sharpness score under mydriasis, photography with the conventional tabletop cameras performed better than the images acquired by the Aurora handheld fundus camera (<0.05). The assessment of mydriasis images regarding image centration (=0.146) and visible range (=0.945) did not reach a significant difference(Table 4).

    We compared the ability to reveal common manifestations of DR between the handheld and tabletop fundus cameras (Table 5). Thesensitivity and specificity to detect microaneurysms reached 94.4% (95%CI: 87.0%-100.0%) and 98.4% (95%CI: 97.3%-99.5%), respectively, using the Aurora camera, compared to 89.7% (95%CI: 80.2%-99.3%) and 98.6% (95%CI: 97.6%-99.6%) using the conventional tabletop camera (Table 6). Detection of retinal hemorrhage, hard exudation, and macular edema were comparable, with that of the AUC of the handheld fundus camera being slightly lower. When detecting referable DR, the Aurora camera obtained an AUC of 88.2%(95%CI: 83.5%-92.8%), corresponding to a sensitivity of 82.1% (95%CI: 72.1%-92.2%) and a specificity of 97.4%(95%CI: 95.4%-99.5%), when compared to 92.7% (95%CI:85.9%-99.6%) and 95.9% (95%CI: 93.2%-98.5%) using the conventional tabletop camera. The corresponding ROC curves are shown in Figure 2.

    The performance of AI detection of DR using the Phoebus Algorithm is shown in Table 6. On images taken from the handheld camera, the Phoebus Algorithm achieved an AUC of 77.8% (95%CI 70.2%-85.4%) when detecting retinal hemorrhage, corresponding to a sensitivity of 73.9% (95%CI 61.2%-86.6%) and a specificity of 81.5% (95%CI 78.0%-84.9%). When detecting hard exudation, the Phoebus Algorithm obtained an AUC of 76.7% (95%CI 70.5%-83.0%),corresponding to a sensitivity of 87.5% (95%CI 78.1%-96.9%) and a specificity of 65.4% (95%CI 61.2%-69.7%). For the referral requirements, the Phoebus Algorithm achieved an AUC of 64.8 (95%CI 59.6%-70.1%), corresponding to a sensitivity of 88.2% (95%CI 79.4%-97.1%) and a specificity of 40.7% (95%CI 34.1%-47.2%). The corresponding ROC curves are shown in Figure 3.

    這自然也包括占星術(shù),“在俘囚期時代,即使是在巴比倫當(dāng)?shù)?,第二以賽亞便不止嘲諷一般的巴比倫巫師,而且特別也嘲諷了巴比倫的天文學(xué)與占星術(shù)。到了俘囚期之后與拉比時代,星宿在以色列毫無用武之地的原則依然存在?!盵注][德]韋伯:《古猶太教》,康樂、簡美惠譯,桂林:廣西師范大學(xué)出版社,2007年,第268頁。 而占星術(shù)在中國是表明王朝合理性的永恒證據(jù),儒家或儒教根本不會去觸動這一自新石器晚期巫酋時代就業(yè)已形成的根深蒂固的觀念,并且作為歷代王朝的主要輔助者或捍衛(wèi)者,儒家只會去不斷改善和強(qiáng)化這一傳統(tǒng);故占星術(shù)同樣也是儒家或儒教的深厚傳統(tǒng)。

    DISCUSSION

    In this study, we introduced a new handheld Optomed Aurora fundus camera, and found it significantly better than traditional tabletop fundus cameras regarding image quality during the non-mydriasis state. The detections of different signs of DR were comparable with the tabletop cameras. The Aurora fundus camera combined with an autonomous AI system had high sensitivity and specificity for DR detection. Furthermore,it was safe and effective in the detection of referable DR in real practice.

    During the last two decades, automated image diagnosis based on AI has been used for detection and classification of DR with the advantages of increased efficiency, reproducibility, and coverage of screening programs. However, application in real world situations remains a challenge due to inconsistent image quality and other aspects such as comorbidity. The accuracy of screening by fundus photography is highly dependent on the performance in detecting different manifestations of DR, using either manual grading or AI-assisted grading. The performances in DR screening between the Aurora and tabletop cameras were comparable in principle. It is worth noting that the Aurora was better than the tabletop cameras in screening sensitivity for detecting microaneurysms (94.4%89.7%),possibly because of the better image quality of the Aurora during the non-mydriasis state. The sensitivity and specificity of the Aurora in the detection of referral-warranted DR were 82.1% and 97.4%, respectively, which met the criteria of The British Diabetic Association, when considering 80% sensitivity and 95% specificity for a viable DR screening program.Overall, these results indicated a satisfactory quality of Aurora for AI-assisted grading.

    二是參考標(biāo)桿管理,對標(biāo)對表明確??瓢l(fā)展方向。結(jié)合建設(shè)西南一流、國內(nèi)有較大影響力的現(xiàn)代化大型三甲綜合醫(yī)院發(fā)展目標(biāo),醫(yī)院要求各??迫鎸?biāo)《國家區(qū)域醫(yī)療中心設(shè)置標(biāo)準(zhǔn)(綜合醫(yī)院)》,深入分析存在的差距與不足,通過“走出去、請進(jìn)來”的方式,不斷加大外出進(jìn)修學(xué)習(xí)、外請專家來院指導(dǎo)力度,以實現(xiàn)在日常工作中持續(xù)整改、不斷提升??萍夹g(shù)水平的最終目的。

    基于此,提出了基于生成對抗文本的人臉圖像翻譯方法,相比其他翻譯方法,本文的翻譯結(jié)果更好,在人臉圖像上具有很好的適應(yīng)性。

    Fundus photography has served as a useful tool in detecting and documenting the presence and the progression of retinopathy in diabetic patients in communities. On this basis, the development of digital fundus cameras further facilitates rapid acquisition and interpretation of fundus images and the rapid deployment of retinal imaging for DR screening worldwide. These cameras produce high quality images that can be assessed for the presence of DR by eye care providers (optometrists or ophthalmologists)or trained readers in a deferred manner on site or remotely.Moreover, many computer-aided algorithms for automated image analysis have been developed, which are expected to be a promising alternative for retinal fundus image analysis for future applications in eye care. Artificial intelligence(AI) systems have been widely demonstrated to lower cost,improve diagnostic accuracy, and increase patient access to DR screening. In April 2018, the United States Food and Drug Administration approved the world's first AI medical device for detecting DR, the IDx-DR.

    Early detection and prompt treatment of DR is the key to reducing preventable vision loss worldwide, which requires regular fundus screening. However, because of the paucity of ophthalmologists in China, there are only about 20 practitioners per million people, which reduces the accessibility of DR screenings. Even in the United States and the United Kingdom, the absolute number of ophthalmologists (49 and 59 ophthalmologists per million people, respectively) still cannot meet the need of a growing number of DR patients,especially in rural areas. Fundus photography has been widely proven to be an effective method to monitor the extent of DR and to identify patients who could benefit from early treatment. However, the large size, weight, and high cost of the conventional tabletop fundus cameras limit its use for large-scale screening in communities lacking a sufficient screening process. In rural and remote communities with few ophthalmologists or table-top fundus cameras, teleophthalmology based on portable fundus cameras used by well-trained physicians is a viable solution to increase DR screening. Therefore, non-mydriatic portable ocular fundus photography is a promising solution when combined with telemedicine. The dimension of our new handheld Aurora fundus camera is approximately 122×202×98 mm, which is much smaller than all tabletop cameras (Table 2), making it possible to be carried and used for training for those without experience.

    We used our self-designed Phoebus algorithm system to examine the performance in detecting DR. The system had independent, validated detectors for lesions characteristic of DR, including retinal hemorrhages, hard exudates, and macular edemas, the outputs of which were then fused into a DR referral requirement output, using a separately trained and validated machine learning algorithm. Several studies have reported the diagnostic performance of AI-based software in the detection of referable DR. The published results appeared promising, showing a sensitivity ranging from 74% to 92.5%,and a specificity between 73.3% and 98.5%. In the present study, the sensitivity and specificity of the Phoebus Algorithm system in identifying referable DR was 88.2% and 40.7%,respectively, which met the FDA superiority sensitivity cut-offs of 85%, but did not reach a specificity of 82.5%. However,in contrast, its sensitivity and specificity of macular edema were 44.1% and 90.1%, respectively. One of the possible reasons was that macular edema is not easily captured using 2-dimensional fundus photographs. In contrast, optical coherence tomography, as a standard diagnostic tool for the assessment of intra- and subretinal fluids, is more sensitive in detecting macular edemas. Sensitivity is a patient safety criterion, because the AI system's primary goal is to identify as many potential patients with DR that require further evaluation by eye care providers. Tanreported an algorithm that achieved a sensitivity and specificity of 62.57% and 98.93%,respectively, for retinal hemorrhages. Our detection sensitivity and specificity of retinal hemorrhages were 73.9% and 81.5%,respectively, with the corresponding AUC of 77.8%. The AIassisted grading system of both mydriatic and non-mydriatic images could therefore be valuable in DR screening.

    This study had some limitations. First, the inclusion of multiples images was from multiple devices with different fields of view and resolutions. However, it could also be a strength for the resulting algorithms, which could be more reliable in the real world with different camera brands or types.Second, the AI-based specificity of referable DR was relatively low, which could affect the number of people who received a referral but did not actually need one because they had only no DR or mild DR. This could have been due to the small sample size of the study. Real-world data of more DR patients will be needed to improve the analysis.

    In conclusion, our study showed that the handheld Aurora fundus camera was well-suited for DR screening with or without mydriasis. This camera had high sensitivity of DR detection as well as satisfactory image quality, but its specificity needs to be improved with better modeling of the data. Our Phoebus AI system helped to improve DR screening. Use of a handheld fundus camera with an AI system was safe and effective in the detection of referable DR in the real world practice.

    葉曉曉不慌不忙,眨著單眼皮的小眼睛微微一笑,說:“從我的眼神。我的眼睛告訴你的是純真,不是隱晦和暗示什么。”

    制造任務(wù)特征主要描述了該任務(wù)中區(qū)別于其他任務(wù)的典型特征信息,包括加工特征、設(shè)備特征和工藝特征等。例如某軸承加工任務(wù),其制造任務(wù)特征為車削加工、車床、材料、尺寸等。該特征的確定一般根據(jù)制造任務(wù)所加工的產(chǎn)品對象的工藝過程特點來確定該制造任務(wù)執(zhí)行過程中的制造任務(wù)特征。

    Supported by the National Natural Science Foundation of China (No.81970845); European Union's Horizon 2020 research and innovation programme under grant agreement (No.778089).

    None;None;is an employee of Shanghai Phoebus Medical Co. Ltd.None;None;None;None;None;None;None.

    猜你喜歡
    巴比倫儒教人臉
    圖書易學(xué)與儒教建構(gòu):喻國人思想研究
    原道(2022年2期)2022-02-17 00:56:54
    有特點的人臉
    無聲之聲:明末清初政統(tǒng)與儒教中的女學(xué)
    原道(2020年2期)2020-12-21 05:46:54
    道統(tǒng)的宗教化:王啟元儒教思想研究
    原道(2020年2期)2020-12-21 05:46:50
    巴比倫餐廳酒吧
    巴比倫傳奇
    三國漫——人臉解鎖
    動漫星空(2018年9期)2018-10-26 01:17:14
    科爾德威與巴比倫城的考古發(fā)掘
    大眾考古(2015年3期)2015-06-26 08:20:28
    巴比倫人
    馬面部與人臉相似度驚人
    亚洲情色 制服丝袜| 久久久国产一区二区| 久热这里只有精品99| 久久久精品94久久精品| 我的老师免费观看完整版| 久久久国产欧美日韩av| videossex国产| 国产免费一级a男人的天堂| 国产黄色视频一区二区在线观看| 国产一区二区三区av在线| 色5月婷婷丁香| 六月丁香七月| 国产一区二区在线观看av| 欧美区成人在线视频| 人妻 亚洲 视频| 日本黄色片子视频| 亚洲国产最新在线播放| 人人妻人人澡人人看| 伊人亚洲综合成人网| 尾随美女入室| 日韩三级伦理在线观看| 国产日韩欧美在线精品| 国产亚洲91精品色在线| 色94色欧美一区二区| 99久国产av精品国产电影| 中文天堂在线官网| 夜夜爽夜夜爽视频| 精品久久久精品久久久| 大码成人一级视频| av天堂中文字幕网| 国产午夜精品一二区理论片| a 毛片基地| 国产成人a∨麻豆精品| 99热网站在线观看| 国产精品一区二区三区四区免费观看| 亚洲va在线va天堂va国产| 久久综合国产亚洲精品| 国产伦在线观看视频一区| 一边亲一边摸免费视频| 伦理电影大哥的女人| 久久精品久久久久久久性| 亚洲精品国产色婷婷电影| 日韩人妻高清精品专区| 午夜免费观看性视频| 老司机影院成人| 我的女老师完整版在线观看| 国产在线免费精品| 国产日韩欧美视频二区| 99热网站在线观看| 人人妻人人爽人人添夜夜欢视频 | 精品国产一区二区久久| 国产精品一区二区性色av| 一个人看视频在线观看www免费| 最近手机中文字幕大全| 久久99精品国语久久久| 欧美激情国产日韩精品一区| 中文字幕免费在线视频6| 亚洲欧美中文字幕日韩二区| 黑人高潮一二区| 男女啪啪激烈高潮av片| 久久久久国产网址| 尾随美女入室| 日韩在线高清观看一区二区三区| 乱人伦中国视频| 亚洲精品日本国产第一区| 精品卡一卡二卡四卡免费| 各种免费的搞黄视频| 街头女战士在线观看网站| 免费大片黄手机在线观看| 五月天丁香电影| 免费大片18禁| 伊人亚洲综合成人网| 日本黄色日本黄色录像| 丰满少妇做爰视频| 男女边摸边吃奶| 精品亚洲乱码少妇综合久久| 校园人妻丝袜中文字幕| 欧美日韩在线观看h| 精品一区二区三卡| 黄色视频在线播放观看不卡| 国产精品三级大全| 91aial.com中文字幕在线观看| 三级国产精品欧美在线观看| 久久亚洲国产成人精品v| 中文字幕人妻熟人妻熟丝袜美| 韩国av在线不卡| 美女cb高潮喷水在线观看| 亚洲av男天堂| 男女免费视频国产| 久久久a久久爽久久v久久| 我要看黄色一级片免费的| 男女免费视频国产| 99热这里只有精品一区| 国内揄拍国产精品人妻在线| 国产在线免费精品| 免费少妇av软件| 国产av国产精品国产| 菩萨蛮人人尽说江南好唐韦庄| 两个人的视频大全免费| 久久毛片免费看一区二区三区| 狂野欧美激情性bbbbbb| 国产 一区精品| 亚洲高清免费不卡视频| 日韩精品有码人妻一区| 国产女主播在线喷水免费视频网站| 99re6热这里在线精品视频| 夜夜爽夜夜爽视频| 丝瓜视频免费看黄片| 免费在线观看成人毛片| 成人国产av品久久久| 伦理电影免费视频| 久久精品国产自在天天线| 免费观看在线日韩| 亚洲精华国产精华液的使用体验| 一级黄片播放器| 国产亚洲精品久久久com| 少妇人妻精品综合一区二区| 男女边吃奶边做爰视频| 国产av一区二区精品久久| 天美传媒精品一区二区| 国产 一区精品| 国产成人freesex在线| 亚洲欧美一区二区三区国产| 久久精品久久久久久噜噜老黄| 看免费成人av毛片| 内地一区二区视频在线| 大香蕉97超碰在线| 国语对白做爰xxxⅹ性视频网站| 视频中文字幕在线观看| 狂野欧美激情性xxxx在线观看| 亚洲av.av天堂| 日本午夜av视频| 汤姆久久久久久久影院中文字幕| av天堂中文字幕网| 日韩成人伦理影院| 妹子高潮喷水视频| 亚洲精品国产av成人精品| 久久人人爽人人爽人人片va| 亚洲精品乱码久久久久久按摩| 欧美激情国产日韩精品一区| 大又大粗又爽又黄少妇毛片口| 国产爽快片一区二区三区| 人妻少妇偷人精品九色| 99久久综合免费| 成人18禁高潮啪啪吃奶动态图 | 波野结衣二区三区在线| h视频一区二区三区| 另类精品久久| 一区二区三区四区激情视频| 精品久久久久久电影网| 男女免费视频国产| 大陆偷拍与自拍| 夜夜看夜夜爽夜夜摸| 黑丝袜美女国产一区| 黄色日韩在线| 国产午夜精品一二区理论片| 韩国av在线不卡| 黄色怎么调成土黄色| 久久久久久伊人网av| 美女国产视频在线观看| 亚洲怡红院男人天堂| 国产熟女欧美一区二区| 欧美最新免费一区二区三区| 国产一区二区三区综合在线观看 | 欧美精品一区二区大全| 午夜影院在线不卡| 老熟女久久久| 午夜精品国产一区二区电影| 欧美 亚洲 国产 日韩一| 国产视频首页在线观看| 2018国产大陆天天弄谢| 国产精品欧美亚洲77777| av又黄又爽大尺度在线免费看| 99久久中文字幕三级久久日本| 亚洲一区二区三区欧美精品| 天天操日日干夜夜撸| 五月开心婷婷网| 欧美精品高潮呻吟av久久| 免费观看无遮挡的男女| 自拍欧美九色日韩亚洲蝌蚪91 | 国产成人午夜福利电影在线观看| 人人妻人人澡人人爽人人夜夜| 午夜免费观看性视频| 老女人水多毛片| 亚洲欧美中文字幕日韩二区| 美女cb高潮喷水在线观看| 偷拍熟女少妇极品色| 十分钟在线观看高清视频www | 免费观看在线日韩| 人人妻人人看人人澡| 97超碰精品成人国产| 少妇精品久久久久久久| 国产一区有黄有色的免费视频| 大又大粗又爽又黄少妇毛片口| 少妇的逼水好多| 亚洲国产精品999| 日韩成人伦理影院| 国产精品不卡视频一区二区| 十八禁高潮呻吟视频 | 国产精品一区二区在线不卡| 草草在线视频免费看| 少妇丰满av| 两个人的视频大全免费| 看免费成人av毛片| 美女中出高潮动态图| 日韩精品免费视频一区二区三区 | 26uuu在线亚洲综合色| 日韩av免费高清视频| 婷婷色综合www| 日本黄色片子视频| 少妇被粗大的猛进出69影院 | 久久久久久久久久成人| 熟女电影av网| 亚洲中文av在线| 国产精品人妻久久久久久| 人妻制服诱惑在线中文字幕| 亚洲av中文av极速乱| 日本午夜av视频| 中文天堂在线官网| 女人久久www免费人成看片| 黄色欧美视频在线观看| 精品亚洲乱码少妇综合久久| 亚洲精品一区蜜桃| 十八禁高潮呻吟视频 | av黄色大香蕉| 精品久久久噜噜| 欧美97在线视频| 国产在线男女| 国产欧美日韩一区二区三区在线 | 纵有疾风起免费观看全集完整版| 久久久久久人妻| 香蕉精品网在线| 99九九在线精品视频 | 各种免费的搞黄视频| 99热国产这里只有精品6| 欧美精品人与动牲交sv欧美| 人妻夜夜爽99麻豆av| 天堂中文最新版在线下载| 国产黄片美女视频| 最近中文字幕2019免费版| 精品熟女少妇av免费看| 日韩欧美 国产精品| 日本黄大片高清| 亚洲中文av在线| 亚洲成人av在线免费| 伦精品一区二区三区| 亚洲精品一二三| 九草在线视频观看| 看十八女毛片水多多多| 久久人妻熟女aⅴ| 这个男人来自地球电影免费观看 | 十八禁网站网址无遮挡 | 日韩制服骚丝袜av| 国产男女内射视频| 18禁在线播放成人免费| 亚洲伊人久久精品综合| 看非洲黑人一级黄片| 最新的欧美精品一区二区| 天天躁夜夜躁狠狠久久av| 纵有疾风起免费观看全集完整版| a级毛片在线看网站| 亚洲一区二区三区欧美精品| 18禁在线无遮挡免费观看视频| 成人无遮挡网站| 中文字幕精品免费在线观看视频 | 精品少妇久久久久久888优播| 丰满迷人的少妇在线观看| 视频中文字幕在线观看| 精品少妇内射三级| 日韩欧美精品免费久久| 亚洲欧美中文字幕日韩二区| 久久精品国产亚洲网站| 免费看日本二区| 亚洲国产毛片av蜜桃av| 在线观看人妻少妇| 大又大粗又爽又黄少妇毛片口| 久久久久久久久久成人| 国产伦精品一区二区三区四那| 亚洲欧美成人精品一区二区| 黄色欧美视频在线观看| 久久久久国产精品人妻一区二区| 亚洲精品国产av成人精品| 亚洲情色 制服丝袜| 亚洲国产精品专区欧美| 天天躁夜夜躁狠狠久久av| 国产永久视频网站| 爱豆传媒免费全集在线观看| 亚洲精品亚洲一区二区| 免费久久久久久久精品成人欧美视频 | 三级国产精品欧美在线观看| 久久久久视频综合| 夜夜骑夜夜射夜夜干| 亚洲精品一区蜜桃| 看免费成人av毛片| 少妇人妻一区二区三区视频| 亚洲,一卡二卡三卡| 极品教师在线视频| 少妇精品久久久久久久| av福利片在线观看| 国内揄拍国产精品人妻在线| 欧美精品国产亚洲| 亚洲欧美日韩卡通动漫| 国产片特级美女逼逼视频| 麻豆成人午夜福利视频| 精品人妻一区二区三区麻豆| 亚洲欧美日韩东京热| 国产亚洲5aaaaa淫片| 97在线视频观看| 国产片特级美女逼逼视频| 日本91视频免费播放| 亚洲国产日韩一区二区| 蜜臀久久99精品久久宅男| 亚洲精品色激情综合| 亚洲va在线va天堂va国产| 在线亚洲精品国产二区图片欧美 | 一级毛片我不卡| 乱系列少妇在线播放| 秋霞伦理黄片| 日韩av不卡免费在线播放| 我要看日韩黄色一级片| 秋霞在线观看毛片| 伦精品一区二区三区| 精品久久久久久久久亚洲| 久久 成人 亚洲| 国产在线一区二区三区精| 欧美三级亚洲精品| 黑人猛操日本美女一级片| 一级毛片我不卡| 精品99又大又爽又粗少妇毛片| 18+在线观看网站| 亚洲精品aⅴ在线观看| 国产亚洲91精品色在线| 在线 av 中文字幕| 国产在线男女| 一级,二级,三级黄色视频| 五月玫瑰六月丁香| 韩国av在线不卡| 午夜福利,免费看| 久久国产乱子免费精品| 91精品伊人久久大香线蕉| 午夜精品国产一区二区电影| 欧美日韩综合久久久久久| 五月玫瑰六月丁香| 国产精品一区www在线观看| 尾随美女入室| 五月伊人婷婷丁香| 好男人视频免费观看在线| 亚洲av成人精品一区久久| 久久热精品热| 搡老乐熟女国产| 在线免费观看不下载黄p国产| 在线亚洲精品国产二区图片欧美 | 久热久热在线精品观看| 欧美97在线视频| 99国产精品免费福利视频| 中文欧美无线码| 中文精品一卡2卡3卡4更新| 国产中年淑女户外野战色| 精品亚洲成国产av| 插逼视频在线观看| 大码成人一级视频| 丝袜脚勾引网站| 赤兔流量卡办理| 久久精品久久久久久噜噜老黄| 美女cb高潮喷水在线观看| 国产午夜精品一二区理论片| 汤姆久久久久久久影院中文字幕| 免费观看性生交大片5| 国产精品国产三级专区第一集| 一级毛片久久久久久久久女| 亚洲图色成人| 国产成人精品久久久久久| 欧美性感艳星| 高清毛片免费看| 亚洲欧美精品自产自拍| 在线观看国产h片| 中文字幕免费在线视频6| 亚洲av欧美aⅴ国产| 黄色怎么调成土黄色| 久久久a久久爽久久v久久| 人妻夜夜爽99麻豆av| 成人特级av手机在线观看| 成人18禁高潮啪啪吃奶动态图 | 啦啦啦视频在线资源免费观看| 成年av动漫网址| 成人亚洲精品一区在线观看| 七月丁香在线播放| 一级黄片播放器| 久久亚洲国产成人精品v| 只有这里有精品99| 国产日韩一区二区三区精品不卡 | 卡戴珊不雅视频在线播放| 性色av一级| 国产av码专区亚洲av| 午夜激情久久久久久久| 如何舔出高潮| 高清黄色对白视频在线免费看 | 少妇熟女欧美另类| 亚洲人成网站在线观看播放| 一区二区三区精品91| 好男人视频免费观看在线| 91成人精品电影| 男人舔奶头视频| 国产成人免费无遮挡视频| 亚洲国产毛片av蜜桃av| a级毛片在线看网站| 久久综合国产亚洲精品| 国产日韩欧美亚洲二区| 免费观看在线日韩| 噜噜噜噜噜久久久久久91| 99热这里只有精品一区| 国产成人精品无人区| 午夜免费鲁丝| 99热这里只有是精品50| 日本av免费视频播放| 夜夜骑夜夜射夜夜干| 亚洲国产精品999| 一本—道久久a久久精品蜜桃钙片| 免费在线观看成人毛片| 老司机影院毛片| 亚洲精品国产色婷婷电影| 国产在线一区二区三区精| 久久免费观看电影| 久久 成人 亚洲| 80岁老熟妇乱子伦牲交| 一级毛片 在线播放| 午夜老司机福利剧场| av黄色大香蕉| 久久99一区二区三区| 久久人人爽人人爽人人片va| 中文字幕亚洲精品专区| 看免费成人av毛片| 99久久中文字幕三级久久日本| 亚洲四区av| 男女无遮挡免费网站观看| 少妇被粗大猛烈的视频| 综合色丁香网| 日日啪夜夜爽| 两个人的视频大全免费| 久久精品久久精品一区二区三区| 一个人免费看片子| 亚洲美女黄色视频免费看| 大香蕉97超碰在线| 人妻制服诱惑在线中文字幕| 777米奇影视久久| 亚洲人成网站在线播| 亚洲精品亚洲一区二区| 久久午夜福利片| 午夜福利,免费看| xxx大片免费视频| 欧美 日韩 精品 国产| 国产永久视频网站| 成人无遮挡网站| 国产精品99久久久久久久久| av又黄又爽大尺度在线免费看| 18禁动态无遮挡网站| 在线看a的网站| 亚洲综合精品二区| 精品酒店卫生间| av在线播放精品| 午夜影院在线不卡| 五月伊人婷婷丁香| 下体分泌物呈黄色| 三级经典国产精品| 国产成人精品婷婷| 亚洲精品中文字幕在线视频 | 欧美日韩av久久| 伦理电影大哥的女人| 欧美国产精品一级二级三级 | 亚洲精品亚洲一区二区| 少妇裸体淫交视频免费看高清| 日本91视频免费播放| 亚洲av中文av极速乱| 插逼视频在线观看| 99九九线精品视频在线观看视频| 一级爰片在线观看| 久久精品久久久久久噜噜老黄| 在线 av 中文字幕| 国产精品一区二区在线观看99| 亚洲欧洲精品一区二区精品久久久 | 老司机亚洲免费影院| 女人久久www免费人成看片| 丰满迷人的少妇在线观看| 国产欧美日韩精品一区二区| 免费看光身美女| 久久久国产一区二区| 丝瓜视频免费看黄片| 寂寞人妻少妇视频99o| 久久久久人妻精品一区果冻| 日韩视频在线欧美| 自拍偷自拍亚洲精品老妇| 午夜福利视频精品| 国产成人午夜福利电影在线观看| 观看av在线不卡| 国产中年淑女户外野战色| 亚洲中文av在线| 大片电影免费在线观看免费| 丁香六月天网| 亚洲一区二区三区欧美精品| 91久久精品国产一区二区成人| 中文字幕久久专区| 我的女老师完整版在线观看| 嘟嘟电影网在线观看| 在线观看av片永久免费下载| 好男人视频免费观看在线| 成年人免费黄色播放视频 | 国产精品久久久久久精品电影小说| 欧美区成人在线视频| 黄色怎么调成土黄色| 久久av网站| 国产亚洲午夜精品一区二区久久| 久久久国产欧美日韩av| 草草在线视频免费看| 久久久久久久大尺度免费视频| 一区二区三区精品91| 简卡轻食公司| 国产男女超爽视频在线观看| 少妇裸体淫交视频免费看高清| 精品一品国产午夜福利视频| 七月丁香在线播放| 日本91视频免费播放| 国产精品秋霞免费鲁丝片| 自线自在国产av| 亚洲欧美成人综合另类久久久| 欧美成人午夜免费资源| 久久精品国产自在天天线| 国产无遮挡羞羞视频在线观看| 日韩欧美 国产精品| 欧美日韩国产mv在线观看视频| 不卡视频在线观看欧美| 国产男人的电影天堂91| 日日啪夜夜爽| 国产 一区精品| 最近2019中文字幕mv第一页| 人妻夜夜爽99麻豆av| 久久 成人 亚洲| 99国产精品免费福利视频| 国产亚洲最大av| 99久久精品一区二区三区| av免费在线看不卡| 丝瓜视频免费看黄片| 看非洲黑人一级黄片| 超碰97精品在线观看| 自拍偷自拍亚洲精品老妇| 亚洲精品第二区| 一级,二级,三级黄色视频| 国内精品宾馆在线| 亚洲电影在线观看av| 王馨瑶露胸无遮挡在线观看| 国产精品一区二区三区四区免费观看| 国产亚洲最大av| 久热这里只有精品99| 国产一区亚洲一区在线观看| 老熟女久久久| 最新中文字幕久久久久| 丝袜在线中文字幕| 国产精品成人在线| 下体分泌物呈黄色| 国产成人精品久久久久久| 99九九在线精品视频 | 我的女老师完整版在线观看| 十八禁高潮呻吟视频 | 纯流量卡能插随身wifi吗| 少妇被粗大猛烈的视频| 欧美成人午夜免费资源| 草草在线视频免费看| 乱人伦中国视频| 日日撸夜夜添| av在线老鸭窝| 亚洲自偷自拍三级| 青春草视频在线免费观看| 2018国产大陆天天弄谢| 国产免费又黄又爽又色| 免费不卡的大黄色大毛片视频在线观看| 久久久久久久亚洲中文字幕| 搡女人真爽免费视频火全软件| 国产69精品久久久久777片| 国产永久视频网站| 国产精品久久久久久精品电影小说| 国产av码专区亚洲av| 欧美日韩国产mv在线观看视频| 亚洲av二区三区四区| 精品国产国语对白av| av天堂中文字幕网| 性色avwww在线观看| 欧美最新免费一区二区三区| 91精品国产国语对白视频| 女性生殖器流出的白浆| 91久久精品国产一区二区成人| 性高湖久久久久久久久免费观看| 毛片一级片免费看久久久久| 国产高清不卡午夜福利| 国模一区二区三区四区视频| 精品国产露脸久久av麻豆| 亚洲av免费高清在线观看| 成人毛片a级毛片在线播放| 成年人午夜在线观看视频| 成人毛片a级毛片在线播放| 少妇人妻精品综合一区二区| 亚洲精品,欧美精品| 特大巨黑吊av在线直播| 精品一区二区免费观看| 高清在线视频一区二区三区| 各种免费的搞黄视频| 一级毛片aaaaaa免费看小| 成人影院久久| 精品人妻熟女毛片av久久网站| 91精品国产国语对白视频| 美女脱内裤让男人舔精品视频| 高清欧美精品videossex| 美女大奶头黄色视频| 水蜜桃什么品种好| 久久免费观看电影| 韩国高清视频一区二区三区| 国产 一区精品|