陳慧麗 朱鋒 汪漩
摘要:目的 ?探討纖維支氣管鏡下肺泡灌洗輔助治療呼吸機(jī)相關(guān)性肺炎的臨床療效。方法 ?選取2017年4月~2019年8月我院收治的呼吸機(jī)相關(guān)性肺炎患者102例作為研究對象,采用隨機(jī)數(shù)字表法分為對照組和觀察組,每組51例。對照組行常規(guī)治療,觀察組在對照組基礎(chǔ)上行纖維支氣管鏡下肺泡灌洗輔助治療,比較兩組治療效果、炎性因子水平[C-反應(yīng)蛋白(CRP)、白介素-8(IL-8)]。結(jié)果 ?觀察組治療總有效率為96.08%,高于對照組的82.35%,差異有統(tǒng)計學(xué)意義(P<0.05);治療后,兩組CRP、IL-8水平均較治療前降低,且觀察組低于對照組,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 ?經(jīng)纖維支氣管鏡下肺泡灌洗輔助治療呼吸機(jī)相關(guān)性肺炎臨床效果確切,可有效降低患者炎性因子水平,改善炎性反應(yīng),促進(jìn)患者病情恢復(fù)。
關(guān)鍵詞:纖維支氣管鏡;肺泡灌洗;呼吸機(jī)相關(guān)性肺炎
中圖分類號:R563.1 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?文獻(xiàn)標(biāo)識碼:A ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?DOI:10.3969/j.issn.1006-1959.2020.11.032
文章編號:1006-1959(2020)11-0107-02
Abstract:Objective ?To explore the clinical efficacy of fiberoptic bronchoscopic alveolar lavage in the adjuvant treatment of ventilator-associated pneumonia.Methods ?A total of 102 patients with ventilator-associated pneumonia admitted in our hospital from April 2017 to August 2019 were selected as the research object, using the random number table method to divided into control group and observation group, with 51 cases in each group. The control group received routine treatment, and the observation group underwent adjuvant alveolar lavage under the control of the bronchofibroscope, compare the treatment effect and inflammatory factor level [C-reactive protein (CRP), interleukin-8 (IL-8)] changes between the two groups.Results ?The total effective rate of treatment in the observation group was 96.08%, higher than 82.35% that in the control group, the difference was statistically significant(P<0.05); After treatment, the levels of CRP and IL-8 in the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant(P<0.05).Conclusion ?The alveolar lavage under fiberoptic bronchoscopy has a definite clinical effect on the treatment of ventilator-associated pneumonia. It can effectively reduce the level of inflammatory factors, improve the inflammatory response, and promote the recovery of the patient's condition.
Key words:Fiberoptic bronchoscopy;Alveolar lavage;Ventilator-associated pneumonia
呼吸機(jī)相關(guān)肺炎(ventilator-associated pneumonia)是機(jī)械通氣過程中常見且較為嚴(yán)重的并發(fā)癥之一,患者一旦發(fā)生,則易造成脫機(jī)困難,嚴(yán)重者甚至危及生命。由于呼吸機(jī)相關(guān)肺炎的致病菌、發(fā)病因素差異較大,其臨床診斷與治療不同于一般肺炎,病死率較高。據(jù)報道[1],呼吸機(jī)相關(guān)肺炎的病死率為20%~71%。臨床治療呼吸機(jī)相關(guān)性肺炎多采用抗生素,但效果有限,難以達(dá)到預(yù)期,加之抗生素濫用易產(chǎn)生多重耐藥菌,可能導(dǎo)致多重耐藥菌感染,嚴(yán)重影響患者生活質(zhì)量,因此積極探尋更加完善的治療方法具有重要的臨床意義[2]。本研究結(jié)合2017年4月~2019年8月我院收治的102例呼吸機(jī)相關(guān)性肺炎患者的臨床資料,觀察纖維支氣管鏡下肺泡灌洗輔助治療呼吸機(jī)相關(guān)性肺炎的臨床效果,現(xiàn)報道如下。