葶藶子、牽牛子、漢防己“利水三味”在錢氏葶藶丸中的配伍應(yīng)用辨析

殷越 武文杰 王清玉 朱澤華 范詩琪 劉暢

[摘要] 本文借助中華醫(yī)典軟件系統(tǒng)和古籍文獻(xiàn)資料庫及中國知網(wǎng)、萬方數(shù)據(jù)庫，以“葶藶（子）”“（黑）牽牛（子）”“防己”為關(guān)鍵詞，查閱并梳理不同時(shí)代醫(yī)藥著作中記載的三藥合用的方劑72首，其中記載方名為葶藶丸的著作最多，共15部。通過梳理方劑學(xué)發(fā)展脈絡(luò)，從方劑組成及藥量變化的層面得出初步結(jié)論，即錢氏葶藶丸從《太平圣惠方》中化裁而來，并在《圣濟(jì)總錄》中加以變化，可信度高。從藥物功效、性味特點(diǎn)、歸經(jīng)及劑型與煎服法等不同角度剖析葶藶子、牽牛子、漢防己三味具有利水功效的中藥在錢氏葶藶丸中的配伍關(guān)系，并借助現(xiàn)代藥理學(xué)研究進(jìn)展，挖掘中醫(yī)古籍經(jīng)典方劑的臨床應(yīng)用價(jià)值，以期為利用現(xiàn)代科學(xué)技術(shù)手段開展的中藥性味、功效的物質(zhì)基礎(chǔ)研究提供理論參考和依據(jù)。

[關(guān)鍵詞] 利水藥;錢氏葶藶丸;藥物配伍;應(yīng)用辨析

[中圖分類號] R289.1? ? ? ? ? [文獻(xiàn)標(biāo)識碼] A? ? ? ? ? [文章編號] 1673-7210（2019）07（c）-0151-05

Differentiation and analysis of the compatibility application of "Lishui Sanwei" of Lepidium seed， Semen pharbitidis， and Stedhania tetrandra in Qian′s Tingli Pills

YIN Yue1? ?WU Wenjie2? ?WANG Qingyu2? ?ZHU Zehua2? ?FAN Shiqi2? ?LIU Chang2

1.School of Basic Medicine， Heilongjiang University of Chinese Medicine， Heilongjiang Province， Harbin? ?150040， China; 2.Graduate School， Heilongjiang University of Chinese Medicine， Heilongjiang Province， Harbin? ?150040， China

[Absrtact] With the help of Chinese Medical Code Software System and the Ancient Literature Database and China National Knowledge Infrastructure （CNKI）， Wanfang Data Knowledge Service Platform， the " Draba nemorosa， Pharbitis nil （Linn.） Choisy， Stephania tetrandra S. Moore" as the key words， this article looked up and sorted out 72 prescriptions in which the three Chinese herbs were combined as described in the medical books of the different eras. Among them， the books recording the Tingli Pills had the largest number， with the total number 15. Through sorting out the development of prescriptions， the preliminary conclusions were drawn from the composition of the prescriptions and the changes in the doses. Qian′s Pills were transferred from the Peaceful Holy Benevolent Prescriptions and transformed in the General Medical Collection of Royal Benevolence， with high credibility. Through the different effects of drug efficacy， gender taste characteristics， channel tropism， dosage forms and decoction methods， the compatibility of Chinese herbal medicines in Qian′s Pills with scorpion venom， venom and Chinese medicinal herbs were analyzed， and research progress of modern pharmacology was applied to further digging up of the clinical application value in classical prescriptions of ancient Chinese medicine， and provide theoretical reference and basis for the research of substances of Chinese medicine taste and efficacy carried out by modern scientific and technological means.