• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Efficacy of hybrid minimally invasive esophagectomy vs open esophagectomy for esophageal cancer:A meta-analysis

    2019-12-14 09:38:04JiaoYangLingChenKeGeJianLeYang

    Jiao Yang,Ling Chen,Ke Ge,Jian-Le Yang

    Jiao Yang,Ling Chen,Ke Ge,Jian-Le Yang,Department of Infectious Diseases,Zhejiang Hospital,12 Lingyin Road,Hangzhou 310013,Zhejiang Province,China

    Abstract

    Key words: Hybrid minimally invasive esophagectomy; Open esophagectomy;Esophageal cancer

    INTRODUCTION

    Esophageal cancer is the eighth most common cancer worldwide,with nearly 17000 newly diagnosed cases and 15910 deaths recorded annually in the United States alone[1].Despite early diagnosis and advanced therapeutic modalities,including surgical resection,radiotherapy,and chemotherapy,the 5-year overall survival rate is a dismal 15% to 20%[2].Esophageal resection remains the major curative and palliative option for dysphagia.For middle- and lower-third esophageal cancer,the abdominal and right thoracic approach is selected due to good loco-regional control.However,post-esophagectomy morbidity and mortality rates are 30%-50% and 2%-10%,respectively[3],mainly due to endocrinal and metabolic changes.The most frequent complications of esophagectomy are the major pulmonary complications (MPPCs),such as pneumonia and acute respiratory distress syndrome.Almost 50% of the postoperative deaths are attributed to MPPCs,which are indicative of poor prognosis.

    Cuschieriet al[4]introduced endoscopic esophagectomy in 1992,which was followed by the development of minimally invasive esophagectomy (MIE),which uses a thoraco-abdominal approach and a combination of laparoscopy,thoracoscopy,and transhiatal laparoscopy.MIE can reduce surgical stress response,decrease blood loss,shorten hospital stay,and lower the incidence of complications[5-7].However,only a few randomized controlled trials (RCTs) and low-quality meta-analysis have evaluated its clinical outcomes,in terms of tumor and lymph node clearance,and the safety profile.Hybrid MIE (HMIE) is performed using an Ivor-Lewis procedure,viaa thoracoscopic-laparotomy and laparoscopic gastric mobilization-thoracotomy,for tumors of the mid-lower esophagus.A three stage McKeown’s procedure,with an additional left cervical incision,has been developed for the upper third of the esophagus.Open esophagectomy is performed by starting with an open right thoracotomy to mobilize the esophagus,followed by an open laparotomy to mobilize and pull the stomach to the neck for anastomosis.Therefore,HMIE may improve perioperative outcomes.The aim of this study was to compare the efficacy of open esophagectomy (OE) and HMIE in esophageal cancer patients.

    MATERIALS AND METHODS

    Literature search

    PubMed,EMBASE,and Cochrane Library database s were searched for studies published till February 1,2019 using the followingKey words:Open esophagectomy,Hybrid minimally invasive esophagectomy,minimally invasive esophagectomy,and esophageal cancer.In addition,the reference lists of the eligible studies were manually searched to include additional studies.

    Study selection

    The inclusion criteria for the studies were as follows:(1) RCTs and non-RCTs; (2)Including patients with esophageal cancer; (3) Comparing the outcomes of OE and HMIE; and (4) Evaluating intraoperative outcomes and postoperative outcomes of both modalities.The exclusion criteria were:(1) In languages other than English; (2)Lacking comparison of OE and HMIE; and (3) Case reports and duplicate publications.

    Data extraction

    Two authors (Jiao Yang and Ling Chen) evaluated the titles,abstracts,and the reference lists of the publications,and independently extracted the data of intraoperative outcomes (lymph node yield,blood loss,and operative time) and postoperative outcomes (the rates of total complications,pulmonary complications,cardiac complications,and anastomotic leak,the duration of intensive care unit (ICU)stay and hospital stay,and total 30-d and 90-d mortality).Any disagreements were resolved by discussion with a third investigator (Ke Ge).For case-control studies,the Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of the eligible studies,and those with a score ≥ 6 were included.Quality of RCTs was evaluated using the risk bias of Cochrane Collaboration tool.

    Statistical analysis

    All analyses were performed with the RveMan5.3 tool (Nordic Cochrane Centre,Cochrane Collaboration).Study heterogeneity was assessed usingχ2and I2tests.A fixed-effects model was used whenI2was < 50% orP> 0.1,indicating no significant heterogeneity amongst the studies,and a random-effects model was used when I2was> 50% orP< 0.1.Odds ratio (OR),standard mean difference (SMD),and 95%confidence interval (CI) were used as effect measurements,andP< 0.05 was considered statistically significant.Publication bias was evaluated by funnel plots and sensitivity analysis was applied to assess the stability of results.

    RESULTS

    Characteristics of selected studies

    A total of 17 studies,including 2 RCTs[8,9]and 15 case-control studies[10-24],were eligible for the meta-analysis.The studies included 2397 esophageal carcinoma patients,of which 1170 received HMIE and 1227 underwent OE.The detailed search strategy is shown in Figure1.The baseline characteristics and quality of the included studies are summarized in Table1,Table2,Table3,and Table4.

    Intraoperative outcomes

    Lymph node yield:Nine studies reported the lymph node yield,with no significant difference between the HMIE with different approaches and OE groups (SMD = 0.11;95%CI:-0.08,0.30;P= 0.26; Table5).Since significant heterogeneity (I2= 65% andP=0.004) was observed amongst the studies,a random-effects model was utilized.Then,subgroup analysis was used to compare HMIE with laparoscopy and thoracotomy and OE.Patients with laparoscopy and thoracotomy (HMIE) presented no more lymph node yield compared to those with OE (SMD = 0.19; 95%CI:-0.00,0.37;P=0.05; Table5).

    Blood loss:Six trials evaluated blood loss,which was also analyzed using the random-effects model due to significant heterogeneity (I2= 58% andP= 0.04).HMIE with different strategies resulted in significantly lower blood loss compared to OE(SMD = -0.43; 95%CI:-0.66,-0.20;P= 0.0002; Table5).In the subgroup analysis,HMIE using laparoscopy and thoracotomy showed priority to OE in decreasing the blood loss (SMD = -0.51; 95%CI:-0.74,-0.27;P< 0.0001; Table5)

    Operative time:Twelve studies involving 1630 patients recorded the operative time,and displayed significant heterogeneity in the outcome (I2= 92% andP< 0.00001).However,HMIE with different approaches or HMIE with laparoscopy and thoracotomy did not significantly decrease the duration of operation (SMD = 0.24;95%CI:-0.14,0.61;P= 0.22 and SMD = 0.10; 95%CI:-0.33,0.52;P= 0.65,respectively;Table5).

    Postoperative outcomes

    Complications:Fourteen trials provided data of the total complications,and showed no significant differences between the HMIE with different approaches group and OE group (OR = 0.68; 95%CI:0.46,0.99;P= 0.05; Table6).However,patients with HMIE using laparoscopy and thoracotomy presented less total complications than those with OE (OR = 0.62; 95%CI:0.41,0.94;P= 0.02; Table6).Total HMIE and HMIE with laparoscopy and thoracotomy were associated with less pulmonary complications than OE (OR = 0.72; 95%CI:0.57,0.90;P= 0.004 and OR = 0.69; 95%CI:0.53,0.90;P=0.005,respectively; Table6),whereas the incidences of cardiac complications (OR =0.91; 95%CI:0.62,1.34;P= 0.64 and OR = 0.97; 95%CI:0.65,1.43;P= 0.86,respectively;Table6) and anastomotic leak (OR = 0.95; 95%CI:0.67,1.35;P= 0.78 and OR = 0.99;95%CI:0.67,1.46;P= 0.96,respectively; Table6) were similar.

    Hospital and ICU stays:Thirteen studies reported duration of hospital stay with significant heterogeneity (I2= 57% andP= 0.006),and total HMIE was not associated with significantly reduced duration of hospital stay (SMD = -0.13; 95%CI:-0.28,0.01;P= 0.08; Table6).However,shorter hospital stay showed in patients with HMIE using laparoscopy and thoracotomy than those with OE (SMD = -0.37; 95%CI:-0.64,-0.09;P= 0.009; Table6).

    In addition,the duration of ICU stay was similar in total HMIE or HMIE with laparoscopy and thoracotomy group and OE group (SMD = -0.01; 95%CI:-0.21,0.19;P= 0.93 and SMD = -0.05; 95%CI:-0.37,0.27;P= 0.76,respectively; Table6).

    Mortality:No significant heterogeneity was detected amongst the studies reporting the total,30-d,and 90-d mortality rates,which were similar in total HMIE or HMIE with laparoscopy and thoracotomy group and OE group (total mortality:OR = 0.70,95%CI:0.47,1.06,P= 0.09 and OR = 0.65,95%CI:0.4,1.07,P= 0.09,respectively; 30-d mortality:OR = 1.00,95%CI:0.45,2.23,P= 0.99 and OR = 1.10,95%CI:0.47,2.59,P=0.82,respectively; 90-d mortality:OR = 0.80,95%CI:0.43,1.48,P= 0.47 and OR = 0.80,95%CI:0.43,1.48,P= 0.47,respectively; Table6).

    Publication bias:Publication bias was evaluated for the outcomes of pulmonary complications,cardiac complications,anastomotic leak,and total mortality and none was detected (Figure2).

    Sensitivity analysis

    We removed any single trial,chose different effect models,and conducted subgroup analysis,and the outcomes presented no significant changes,suggesting that the results were stable.

    Figure1 Flow diagram showing the selection process of relevant literature.

    DISCUSSION

    Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide.Surgical resection is the first line of treatment,and includes OE,total MIE,and HMIE.Depending on the surgeon and the hospital,the choice and sequence of surgical approaches differ significantly (transthoracicvstranshiatal,intrathoracicvscervical anastomosis,and the degree of lymphadenectomy).OE is associated with a significantly higher risk of surgical trauma,as well as higher morbidity and mortality compared to other surgeries[25].Sunpaweravonget al[25]conducted a meta-analysis to compare the efficacy of OE and MIE,and found that MIE resulted in fewer perioperative complications and less mortality.In addition,patients with MIE had better quality of life scores compared to those with OE in the global health,pain,and physical activity domains[26].Therefore,total MIE would be the ideal choice.But the technical difficulties,the long learning curve,and low reproducibility of the anastomosis limit its use.HMIE has a shorter learning curve while sharing the advantages of MIE.The transition from OE to HMIE may be acceptable.The above information of MIE does not distinguish between the total MIE and HMIE approaches,so whether HMIE is prior to OE is still controversial.In this metaanalysis,we first compared the intraoperative and postoperative outcomes of HMIE and OE in patients with esophageal cancer.

    Many studies show that radical lymph node resection and greater extent of lymphadenectomy are closely associated with higher survival rates[27-30].In this study,there was no significant difference in terms of the number of harvested lymph nodes between total HMIE and OE groups,which is consistent with a previous RCT[8].But there was a trend for patients with HMIE using laparoscopy and thoracotomy with a high rate of lymphadenectomy.Some studies once reported a higher or lower number of lymph nodes harvested in MIE group[31,32].Those discrepancies may be explained by the inconsistency of Current Procedure Terminology codes reported by the operating surgeons.

    Smitherset al[12]reported that patients who underwent HMIE had less blood loss than those undergoing OE,while Yanasootet al[24]showed no significant difference.In our meta-analysis also,the total HMIE group and the HMIE with laparoscopy and thoracotomy group had less blood loss,which could be attributed to the relatively minimal trauma in HMIE.

    Studies also report a longer operative duration of MIE compared to OE[33-35],whichcan result in atelectasis and pneumonia.In our meta-analysis,the operative time was similar for both surgeries.

    Table2 Baseline characteristics

    Postoperative complications,especially pulmonary complications,significantly influence the survival of esophageal cancer patients.The incidences of total complications in patients with total HMIE and OE were 50.2% and 60.1%,respectively,although the lower occurrence after HMIE was not statistically significant.In the subgroup analysis,HMIE with laparoscopy and thoracotomy could largely lower the incidence of total complications than OE (46.55%vs57.74%).The TIME trial showed that MIE resulted in a 70% lower incidence of pneumonia at 2 weeks post-surgery compared to OE[36],which is consistent with our slightly higher incidence of pulmonary complications in OE compared to total HMIE or HMIE with laparoscopy and thoracotomy (25.37%vs32.08% or 24.59%vs31.23%).In contrast,the incidence of cardiac complications and anastomotic leak was not affected by the type of surgery.

    Less pulmonary complications in the total HMIE group did not translate into a significant reduction in the duration of ICU and hospital stay.But HMIE with laparoscopy and thoracotomy presented a more reduction in the duration of hospital stay on the basis of its lower total complications and pulmonary complications.

    Some studies indicate that the prolonged survival associated with HMIE is due to the lower incidence of postoperative complications[37-39].In our meta-analysis,the overall,30-d,and 90-d mortality rates in the total HMIE group were 4.16%,2.52%,and 4.00%,respectivelyvs6.02%,2.40%,and 4.70% in the OE group,indicating a lack of short-term survival benefit with total HMIE.Patients with HMIE using laparoscopy and thoracotomy presented no priority in short-term survival compared to those with OE.Wanget alreported that 6-year overall survival and disease-free survival were 44.7% and 46.1%,respectively,for MIE,indicating that MIE is safe[40].A score-matched study showed that the 2-year overall survival rates based on same pathologic stage were similar between MIE and OE[41].But further studies are still needed to clarify the long-term survival outcomes.

    Our study has several limitations that need to be addressed.First,only two out of the 17 studies were RCTs and the remaining were case-control studies which might have influenced the reliability of the results,although they were consistent with that of one eligible RCT.Second,the studies had variable follow-up duration,neoadjuvant chemoradiotherapy,operating surgeons,pathological stages,histological types and

    Table3 Quality assessment of the eligible studies:Newcastle-Ottawa Scale for case control studies

    location of the tumor,and baseline characteristics of the recruited population.Third,the meta-analysis did not compare the long-term oncological outcomes between HMIE and OE.Last but not the least,we made subgroup analysis between HMIE with laparoscopy and thoracotomy and OE group.But the information associated with HMIE using thoracoscopic-laparotomy approach is little and ambiguous.Therefore,the real impact of laparoscopy compared to thoracoscopy is unclear,and data that can confirm which part of esophagectomy would play an important role in MIE is lacking.

    Taken together,HMIE,especially HMIE with laparoscopy and thoracotomy,has the advantages of reduced blood loss and lower incidence of pulmonary complications compared to OE for patients with esophageal cancer.However,there is no significant difference in overall survival in the two groups.These findings should be explained with caution because our study doesn’t provide the data associated with cancer-specific survival and recurrence.

    Table4 Quality assessment of the eligible studies:Risk bias of Cochrane Collaboration tool for randomized controlled trials

    Table5 Comparison of perioperative outcomes between hybrid minimally invasive esophagectomy and open esophagectomy groups

    Table6 Postoperative outcomes between hybrid minimally invasive esophagectomy group and open esophagectomy groups

    Figure2 Funnel plots of eligible studies.A:Incidence of pulmonary complications; B:Incidence of cardiac complications; C:Incidence of anastomotic leak; D:Total mortality.

    ARTICLE HIGHLIGHTS

    Research background

    The first line treatment regimen for esophageal cancer is still surgical resection and the choice of surgical scheme depends on the surgeon.

    Research motivation

    Now the efficacy comparison of hybrid minimally invasive esophagectomy (HMIE) and open esophagectomy (OE) is still controversial.

    To compare the perioperative and postoperative outcomes of HMIE and OE in patients with esophageal cancer.

    Research objectives

    Research methods

    PubMed,EMBASE,and Cochrane Library databases were searched for related articles.

    Research results

    Seventeen studies including a total of 2397 patients were selected.HMIE was significantly associated with less blood loss (SMD = -0.43,95%CI:-0.66,-0.20; P = 0.0002) and lower incidence of pulmonary complications (OR = 0.72,95%CI:0.57,0.90; P = 0.004).

    Research conclusions

    Compared with OE,HMIE shows less blood loss and pulmonary complications.

    Research perspectives

    Further studies are necessary to evaluate the long-term oncologic outcomes of HMIE.

    97精品久久久久久久久久精品| 亚洲国产欧美在线一区| 国产97色在线日韩免费| 中文字幕最新亚洲高清| 国产精品熟女久久久久浪| 国产成人欧美| 国产伦理片在线播放av一区| 久久久久久久久久久久大奶| 国产成人一区二区三区免费视频网站 | 午夜福利在线免费观看网站| 观看av在线不卡| 9色porny在线观看| 一级a爱视频在线免费观看| 国产成人系列免费观看| av有码第一页| 国产欧美日韩综合在线一区二区| 中国国产av一级| 欧美 亚洲 国产 日韩一| 自线自在国产av| 亚洲,欧美,日韩| 国产精品 国内视频| xxx大片免费视频| 夜夜骑夜夜射夜夜干| 久久精品国产a三级三级三级| 亚洲国产日韩一区二区| 国产精品一国产av| 黑人欧美特级aaaaaa片| 99热全是精品| 国产又色又爽无遮挡免| 一级,二级,三级黄色视频| 女人精品久久久久毛片| 青青草视频在线视频观看| 久久国产精品影院| 另类亚洲欧美激情| 日韩一本色道免费dvd| 又粗又硬又长又爽又黄的视频| 日韩免费高清中文字幕av| 亚洲av成人不卡在线观看播放网 | 一区二区三区精品91| 搡老乐熟女国产| 亚洲精品第二区| h视频一区二区三区| 天天操日日干夜夜撸| av又黄又爽大尺度在线免费看| 精品久久久精品久久久| 91成人精品电影| 波野结衣二区三区在线| 午夜老司机福利片| 亚洲av片天天在线观看| 国产在线一区二区三区精| 看十八女毛片水多多多| 久久这里只有精品19| 少妇猛男粗大的猛烈进出视频| 国产高清视频在线播放一区 | 中文字幕人妻丝袜一区二区| 亚洲av国产av综合av卡| 日韩伦理黄色片| 国产成人av激情在线播放| 亚洲中文字幕日韩| 亚洲av美国av| 香蕉国产在线看| 亚洲情色 制服丝袜| 国产精品国产三级国产专区5o| 国产精品国产av在线观看| 国产精品 国内视频| 一级毛片电影观看| 一边摸一边做爽爽视频免费| 亚洲av美国av| 99精品久久久久人妻精品| 国精品久久久久久国模美| 老司机靠b影院| 捣出白浆h1v1| 视频区图区小说| 中文字幕高清在线视频| 人人妻,人人澡人人爽秒播 | 中文字幕av电影在线播放| 中文字幕制服av| 国产精品九九99| 99热国产这里只有精品6| 国产成人免费无遮挡视频| 18禁观看日本| 久久女婷五月综合色啪小说| 国产97色在线日韩免费| 美女国产高潮福利片在线看| 赤兔流量卡办理| 免费人妻精品一区二区三区视频| 天堂8中文在线网| 国产精品久久久久久精品古装| 欧美黑人欧美精品刺激| 国产熟女午夜一区二区三区| 国产成人免费无遮挡视频| 亚洲伊人色综图| 亚洲九九香蕉| 美女扒开内裤让男人捅视频| 亚洲五月色婷婷综合| 亚洲成人国产一区在线观看 | 国产野战对白在线观看| 免费女性裸体啪啪无遮挡网站| xxx大片免费视频| 老司机在亚洲福利影院| 18禁国产床啪视频网站| 观看av在线不卡| 国产成人精品久久二区二区免费| 涩涩av久久男人的天堂| 男女下面插进去视频免费观看| www.熟女人妻精品国产| 50天的宝宝边吃奶边哭怎么回事| 另类精品久久| 看免费成人av毛片| 国产97色在线日韩免费| 黄色视频在线播放观看不卡| 高清视频免费观看一区二区| 99热国产这里只有精品6| 91九色精品人成在线观看| 国产一区有黄有色的免费视频| 最近最新中文字幕大全免费视频 | 在线精品无人区一区二区三| 日本wwww免费看| 人妻人人澡人人爽人人| 男人添女人高潮全过程视频| 18在线观看网站| av国产精品久久久久影院| 国产爽快片一区二区三区| 国产精品一区二区在线观看99| 久久久久久亚洲精品国产蜜桃av| a 毛片基地| a级片在线免费高清观看视频| 亚洲色图 男人天堂 中文字幕| 亚洲,一卡二卡三卡| 国产在线一区二区三区精| 国产成人精品久久久久久| 大片电影免费在线观看免费| 亚洲熟女毛片儿| 老汉色av国产亚洲站长工具| 两人在一起打扑克的视频| 免费日韩欧美在线观看| 久久久精品免费免费高清| 99国产综合亚洲精品| 国产女主播在线喷水免费视频网站| 精品人妻1区二区| 久久亚洲精品不卡| 亚洲精品美女久久av网站| 男女边吃奶边做爰视频| 大片电影免费在线观看免费| 久久青草综合色| 国产成人免费无遮挡视频| 亚洲欧美激情在线| 美国免费a级毛片| 电影成人av| 亚洲欧美一区二区三区黑人| 婷婷色麻豆天堂久久| 国产免费福利视频在线观看| 亚洲一区二区三区欧美精品| 女人精品久久久久毛片| 亚洲情色 制服丝袜| 国产精品免费视频内射| tube8黄色片| 国产欧美亚洲国产| 亚洲av欧美aⅴ国产| 中文字幕色久视频| 看免费av毛片| 日韩中文字幕欧美一区二区 | 老鸭窝网址在线观看| 午夜老司机福利片| 精品一区二区三区av网在线观看 | 亚洲欧美一区二区三区久久| 狂野欧美激情性bbbbbb| 韩国精品一区二区三区| 亚洲欧美一区二区三区黑人| 精品第一国产精品| 日本91视频免费播放| 亚洲国产欧美一区二区综合| 啦啦啦中文免费视频观看日本| videos熟女内射| 日韩一本色道免费dvd| 亚洲,一卡二卡三卡| 在线观看一区二区三区激情| 在线观看免费日韩欧美大片| 久久精品国产综合久久久| 一区二区日韩欧美中文字幕| 国产成人av教育| 女性被躁到高潮视频| 人妻一区二区av| 菩萨蛮人人尽说江南好唐韦庄| 手机成人av网站| 深夜精品福利| 亚洲成国产人片在线观看| 亚洲三区欧美一区| 人体艺术视频欧美日本| 亚洲av电影在线观看一区二区三区| 亚洲 国产 在线| 欧美精品人与动牲交sv欧美| 中文字幕高清在线视频| 另类亚洲欧美激情| 女人精品久久久久毛片| 欧美日韩黄片免| 久久人妻熟女aⅴ| 精品第一国产精品| 十八禁高潮呻吟视频| 久热这里只有精品99| 国产精品麻豆人妻色哟哟久久| 另类精品久久| 另类亚洲欧美激情| 亚洲国产av影院在线观看| 手机成人av网站| 美女高潮到喷水免费观看| 久久久久国产一级毛片高清牌| 亚洲av综合色区一区| 成年美女黄网站色视频大全免费| 高潮久久久久久久久久久不卡| 精品亚洲成国产av| 国产精品成人在线| 在线 av 中文字幕| 欧美激情极品国产一区二区三区| 亚洲精品国产一区二区精华液| 欧美亚洲日本最大视频资源| 男的添女的下面高潮视频| 中文字幕av电影在线播放| 美女午夜性视频免费| 日本午夜av视频| 欧美人与性动交α欧美软件| 国产在线视频一区二区| 亚洲精品国产一区二区精华液| 天天躁夜夜躁狠狠躁躁| 亚洲人成电影观看| 国产精品久久久久成人av| 亚洲男人天堂网一区| 久久久久久亚洲精品国产蜜桃av| 黄色 视频免费看| 亚洲七黄色美女视频| 久久久久久久精品精品| h视频一区二区三区| 久久久精品国产亚洲av高清涩受| 一级黄片播放器| 精品国产一区二区三区久久久樱花| 国产精品一区二区在线不卡| 国产在线观看jvid| 亚洲人成电影免费在线| 亚洲欧美激情在线| 国产成人精品久久二区二区91| 亚洲,一卡二卡三卡| 每晚都被弄得嗷嗷叫到高潮| 九草在线视频观看| 久久久久视频综合| 久久精品久久久久久久性| 精品国产乱码久久久久久男人| 人人妻人人添人人爽欧美一区卜| 欧美在线黄色| 亚洲欧洲国产日韩| 妹子高潮喷水视频| 天天躁夜夜躁狠狠久久av| 精品高清国产在线一区| 尾随美女入室| 亚洲国产中文字幕在线视频| 精品人妻一区二区三区麻豆| 亚洲色图 男人天堂 中文字幕| 美女国产高潮福利片在线看| 叶爱在线成人免费视频播放| 久久精品久久精品一区二区三区| 少妇被粗大的猛进出69影院| 国产成人欧美在线观看 | 一区在线观看完整版| 一边摸一边抽搐一进一出视频| videosex国产| 精品少妇久久久久久888优播| 国产淫语在线视频| 欧美黄色淫秽网站| 老司机靠b影院| 1024视频免费在线观看| 色婷婷久久久亚洲欧美| www.av在线官网国产| 亚洲欧洲精品一区二区精品久久久| 丝袜喷水一区| 日韩制服骚丝袜av| 晚上一个人看的免费电影| 久久久亚洲精品成人影院| 亚洲欧美一区二区三区久久| 国产精品九九99| 亚洲av电影在线观看一区二区三区| 美女午夜性视频免费| 日韩一卡2卡3卡4卡2021年| 久久精品久久久久久久性| av网站免费在线观看视频| 欧美乱码精品一区二区三区| 五月开心婷婷网| 亚洲国产精品一区三区| 人妻 亚洲 视频| e午夜精品久久久久久久| 999精品在线视频| 这个男人来自地球电影免费观看| 女性被躁到高潮视频| 色网站视频免费| 亚洲欧美日韩高清在线视频 | 天天躁狠狠躁夜夜躁狠狠躁| 国产成人av教育| 国产一级毛片在线| 欧美日韩成人在线一区二区| 少妇 在线观看| 亚洲欧美一区二区三区黑人| 午夜福利影视在线免费观看| 色94色欧美一区二区| 91老司机精品| 午夜福利一区二区在线看| 亚洲国产欧美在线一区| 男女午夜视频在线观看| 老司机午夜十八禁免费视频| 天天躁夜夜躁狠狠躁躁| 在线观看免费午夜福利视频| 美女视频免费永久观看网站| 嫁个100分男人电影在线观看 | 男人操女人黄网站| 亚洲成人免费电影在线观看 | 老司机靠b影院| 欧美亚洲 丝袜 人妻 在线| 午夜激情av网站| 大话2 男鬼变身卡| 国产精品熟女久久久久浪| 成人亚洲欧美一区二区av| 免费在线观看日本一区| 亚洲精品美女久久久久99蜜臀 | 午夜福利在线免费观看网站| 精品少妇内射三级| 国产三级黄色录像| 啦啦啦视频在线资源免费观看| 亚洲男人天堂网一区| 欧美精品av麻豆av| 国产不卡av网站在线观看| 亚洲欧洲日产国产| 美女中出高潮动态图| 一本—道久久a久久精品蜜桃钙片| 成人国产一区最新在线观看 | 波多野结衣av一区二区av| 久久这里只有精品19| 999久久久国产精品视频| 麻豆国产av国片精品| 亚洲熟女毛片儿| 久久精品成人免费网站| 一级黄片播放器| 色精品久久人妻99蜜桃| 亚洲欧美一区二区三区国产| 精品福利永久在线观看| 一边摸一边抽搐一进一出视频| 欧美xxⅹ黑人| 日韩免费高清中文字幕av| 色网站视频免费| 丝袜美足系列| 波野结衣二区三区在线| 欧美乱码精品一区二区三区| 欧美激情高清一区二区三区| 午夜福利影视在线免费观看| 性色av乱码一区二区三区2| 欧美乱码精品一区二区三区| 香蕉丝袜av| 国产免费一区二区三区四区乱码| 国产精品一区二区在线观看99| 国产一区二区 视频在线| 亚洲成人免费av在线播放| 精品福利永久在线观看| 电影成人av| 久久九九热精品免费| av一本久久久久| 亚洲自偷自拍图片 自拍| 黄网站色视频无遮挡免费观看| 国产高清不卡午夜福利| 日本猛色少妇xxxxx猛交久久| 国产欧美日韩一区二区三区在线| 亚洲人成网站在线观看播放| 亚洲av国产av综合av卡| 高清不卡的av网站| 免费在线观看影片大全网站 | 国产免费福利视频在线观看| 亚洲av电影在线观看一区二区三区| 国产深夜福利视频在线观看| 亚洲一码二码三码区别大吗| 一区二区三区四区激情视频| 免费黄频网站在线观看国产| 久久性视频一级片| av国产久精品久网站免费入址| 久热这里只有精品99| 日本一区二区免费在线视频| 美女国产高潮福利片在线看| 亚洲av日韩精品久久久久久密 | 亚洲av片天天在线观看| 久久久精品免费免费高清| 亚洲av成人精品一二三区| 精品福利观看| 午夜福利免费观看在线| √禁漫天堂资源中文www| 老熟女久久久| 免费高清在线观看视频在线观看| 女人爽到高潮嗷嗷叫在线视频| 亚洲,欧美精品.| 中文欧美无线码| 国产精品一区二区免费欧美 | 亚洲欧美中文字幕日韩二区| 一区福利在线观看| 伊人亚洲综合成人网| 国产精品 欧美亚洲| 婷婷色av中文字幕| 黑丝袜美女国产一区| 狠狠婷婷综合久久久久久88av| 精品第一国产精品| 国产爽快片一区二区三区| 狠狠婷婷综合久久久久久88av| 亚洲精品国产一区二区精华液| 黄网站色视频无遮挡免费观看| 成人免费观看视频高清| 日韩av免费高清视频| 欧美日韩黄片免| 亚洲国产欧美一区二区综合| 两个人看的免费小视频| 国产成人系列免费观看| 精品国产一区二区久久| 亚洲精品国产区一区二| 黄频高清免费视频| 人人妻人人添人人爽欧美一区卜| 欧美+亚洲+日韩+国产| 亚洲国产欧美一区二区综合| netflix在线观看网站| 欧美变态另类bdsm刘玥| 日韩伦理黄色片| 色婷婷久久久亚洲欧美| 最近中文字幕2019免费版| 久久久精品94久久精品| 国产日韩欧美亚洲二区| 欧美亚洲 丝袜 人妻 在线| 色婷婷久久久亚洲欧美| 香蕉丝袜av| 无限看片的www在线观看| 天天添夜夜摸| 精品少妇久久久久久888优播| 精品人妻在线不人妻| 日韩中文字幕视频在线看片| 999久久久国产精品视频| 只有这里有精品99| 97人妻天天添夜夜摸| 亚洲九九香蕉| 啦啦啦在线免费观看视频4| 国产伦理片在线播放av一区| 国产男女内射视频| videos熟女内射| 亚洲av成人精品一二三区| 亚洲国产欧美日韩在线播放| 色精品久久人妻99蜜桃| 免费在线观看日本一区| 国产日韩欧美亚洲二区| 18在线观看网站| 国产免费一区二区三区四区乱码| 久久久久精品人妻al黑| www.熟女人妻精品国产| 久久狼人影院| 大香蕉久久成人网| 亚洲自偷自拍图片 自拍| 亚洲国产日韩一区二区| 熟女少妇亚洲综合色aaa.| 亚洲专区中文字幕在线| 久久久亚洲精品成人影院| 色播在线永久视频| 国产精品久久久人人做人人爽| 免费在线观看黄色视频的| 欧美日韩精品网址| 午夜福利在线免费观看网站| 搡老乐熟女国产| 波多野结衣av一区二区av| 91国产中文字幕| 夜夜骑夜夜射夜夜干| 深夜精品福利| 成在线人永久免费视频| 一级片'在线观看视频| 中文字幕制服av| 久久免费观看电影| 中文字幕高清在线视频| 91麻豆精品激情在线观看国产 | 一个人免费看片子| 国产极品粉嫩免费观看在线| 亚洲欧美日韩另类电影网站| 人成视频在线观看免费观看| 欧美人与性动交α欧美软件| 99精国产麻豆久久婷婷| 啦啦啦视频在线资源免费观看| 欧美黑人欧美精品刺激| 激情五月婷婷亚洲| 国产真人三级小视频在线观看| 午夜老司机福利片| 亚洲国产成人一精品久久久| 麻豆国产av国片精品| 国产视频一区二区在线看| av网站免费在线观看视频| 2021少妇久久久久久久久久久| 黄色视频不卡| 夫妻午夜视频| 国产淫语在线视频| 久久久久国产一级毛片高清牌| 国产在线一区二区三区精| 在线观看免费午夜福利视频| 国产精品久久久久成人av| 久久精品国产亚洲av涩爱| 中文字幕色久视频| tube8黄色片| 亚洲成国产人片在线观看| 免费黄频网站在线观看国产| 日韩一卡2卡3卡4卡2021年| 亚洲伊人色综图| 精品国产一区二区久久| 久久久久久久国产电影| 欧美日韩一级在线毛片| 在线亚洲精品国产二区图片欧美| 亚洲人成电影观看| 国产精品一区二区精品视频观看| 美女脱内裤让男人舔精品视频| 99国产精品99久久久久| 亚洲精品美女久久av网站| 国产高清videossex| 18禁国产床啪视频网站| 欧美久久黑人一区二区| www.999成人在线观看| 午夜免费鲁丝| 久久天堂一区二区三区四区| 日韩av免费高清视频| av在线老鸭窝| 亚洲欧洲国产日韩| 免费在线观看影片大全网站 | 自拍欧美九色日韩亚洲蝌蚪91| 999久久久国产精品视频| 这个男人来自地球电影免费观看| 国语对白做爰xxxⅹ性视频网站| 亚洲第一青青草原| 大片电影免费在线观看免费| 亚洲伊人色综图| 成人手机av| 亚洲午夜精品一区,二区,三区| 90打野战视频偷拍视频| 国产日韩一区二区三区精品不卡| 国产成人系列免费观看| 亚洲av成人精品一二三区| av天堂在线播放| 狂野欧美激情性xxxx| 日韩电影二区| 国产男女内射视频| kizo精华| 在线观看国产h片| 精品少妇黑人巨大在线播放| av国产精品久久久久影院| 国产三级黄色录像| 大片免费播放器 马上看| 最近中文字幕2019免费版| 国产成人免费无遮挡视频| 国产在线免费精品| 亚洲av片天天在线观看| 欧美日韩综合久久久久久| 亚洲国产最新在线播放| 中文字幕另类日韩欧美亚洲嫩草| 不卡av一区二区三区| 国产成人精品久久二区二区91| 午夜激情av网站| 十八禁人妻一区二区| 999精品在线视频| 亚洲欧美成人综合另类久久久| av天堂在线播放| 脱女人内裤的视频| 视频区欧美日本亚洲| 一区二区三区乱码不卡18| 久久人妻熟女aⅴ| 成年人午夜在线观看视频| 伊人亚洲综合成人网| 午夜两性在线视频| 国产熟女午夜一区二区三区| 97在线人人人人妻| 色婷婷av一区二区三区视频| 亚洲国产毛片av蜜桃av| 亚洲精品国产一区二区精华液| 女人久久www免费人成看片| 国产黄色视频一区二区在线观看| 日韩一卡2卡3卡4卡2021年| 成人午夜精彩视频在线观看| 中文字幕高清在线视频| 欧美亚洲 丝袜 人妻 在线| 亚洲欧美色中文字幕在线| 午夜免费鲁丝| 美女大奶头黄色视频| 97在线人人人人妻| 亚洲欧美日韩高清在线视频 | 欧美激情极品国产一区二区三区| 国产精品一区二区精品视频观看| 色婷婷av一区二区三区视频| 欧美人与善性xxx| 下体分泌物呈黄色| 性少妇av在线| 一二三四社区在线视频社区8| 下体分泌物呈黄色| 99热网站在线观看| 高清视频免费观看一区二区| 亚洲午夜精品一区,二区,三区| 国产精品秋霞免费鲁丝片| 亚洲国产精品999| 久久久久网色| 精品一区二区三区四区五区乱码 | 欧美中文综合在线视频| 人人妻人人澡人人爽人人夜夜| 又黄又粗又硬又大视频| 亚洲精品日韩在线中文字幕| 亚洲国产成人一精品久久久| bbb黄色大片| 丁香六月天网| 一本色道久久久久久精品综合| 久久久欧美国产精品| www.熟女人妻精品国产| 亚洲,欧美,日韩| 午夜91福利影院| 国产女主播在线喷水免费视频网站| 久热爱精品视频在线9| 亚洲天堂av无毛| av在线app专区| 国产视频首页在线观看| 在线精品无人区一区二区三|