吳國(guó)棟
[摘要] 目的 分析出現(xiàn)肺炎支原體感染的支氣管炎小兒臨床應(yīng)用中藥清熱化痰法聯(lián)合西藥阿奇霉素治療的效果。方法 方便選擇2016年2月—2018年7月該院小兒肺炎支原體感染的支氣管炎123例為對(duì)象,其中61例接受單一阿奇霉素治療,視作對(duì)照組,另外62例接受清熱化痰法聯(lián)合阿奇霉素治療,視作觀察組,比較兩組效果。 結(jié)果 觀察組總有效率為90.32%,高于對(duì)照組73.77%(χ2=5.735 7,P=0.016 6);觀察組治療后咳嗽消除、高熱消退、肺部體征恢復(fù)、肺部陰影消失時(shí)間短于對(duì)照組(t=5.063 1、9.801 6、9.820 7、5.236 4,P=0.000 0);觀察組治療后IL-6、TNF-α、CRP水平均低于對(duì)照組(P<0.05)。 結(jié)論 小兒肺炎支原體感染的支氣管炎臨床治療中選擇清熱化痰法聯(lián)合阿奇霉素能夠更迅速改善臨床癥狀,加快患兒恢復(fù),值得推廣。
[關(guān)鍵詞] 小兒肺炎支原體感染;支氣管炎;清熱化痰法;阿奇霉素;治療
[中圖分類(lèi)號(hào)] R725.6? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1674-0742(2019)05(a)-0160-03
[Abstract] Objective To analyze the clinical effect of traditional Chinese medicine Qingre Huatan method combined with western medicine Azithromycin in the treatment of bronchitis with Mycoplasma pneumoniae infection in children. Methods A total of 123 cases of bronchitis caused by Mycoplasma pneumoniae infection in children in our hospital from February 2016 to July 2018 were convenient selected as subjects. The control group (n=61) cases single azithromycin treatment as, and the observation group (n=62) received heat-clearing and phlegm-resolving therapy combined with azithromycin treatment. The effects of the two groups were compared. Results The total effective rate of the observation group was 90.32%, which was higher than that of the control group (73.77%) (χ2=5.735 7, P=0.016 6). The time of cough elimination, fever subsidence, recovery of pulmonary signs and disappearance of pulmonary shadow in the observation group was shorter than those in the control group (t=5.063 1, 9.801 6, 9.820 7, 5.236 4, P=0.000 0). The levels of IL-6, TNF-a and CRP in the observation group were higher than those in the control group(P<0.05). Conclusion The method of clearing heat and resolving phlegm combined with azithromycin can improve clinical symptoms more quickly and accelerate recovery of children with bronchitis caused by Mycoplasma pneumoniae infection, which is worthy of promotion.
[Key words] Mycoplasma pneumoniae infection in children; Bronchitis; Clearing heat and resolving phlegm method; Azithromycin; Treatment
小兒支氣管炎多由于支原體感染導(dǎo)致,病毒、細(xì)菌、肺炎支原體感染是這一疾病出現(xiàn)的重要機(jī)制,部分為多重感染引起[1]。這一疾病存在比較高的復(fù)發(fā)率,臨床徹底治愈難度大,且如果沒(méi)有及時(shí)得到治療,患兒容易并發(fā)其他癥狀,進(jìn)一步增加治療難度[2-3]。西醫(yī)治療雖然能一定程度緩解臨床癥狀,不過(guò)因?yàn)樾旱挚沽^差,所以長(zhǎng)期用藥會(huì)有明顯副反應(yīng),影響整體預(yù)后[4]。當(dāng)前逐漸發(fā)現(xiàn)中醫(yī)藥方法在臨床治療中的價(jià)值,該研究具體分析中醫(yī)清熱化痰法聯(lián)合西藥阿奇霉素用于肺炎支原體感染的小兒支氣管炎治療中的價(jià)值,以該院2016年2月—2018年7月123例患兒為對(duì)象,現(xiàn)報(bào)道如下。
1? 資料與方法
1.1? 一般資料
方便選取該院收治的123例小兒肺炎支原體感染的支氣管炎為對(duì)象,全部患兒病程均不超過(guò)72 h,且沒(méi)有接受過(guò)抗生素治療。根據(jù)治療方式不同分為2組,觀察組62例,31例男以及31例女, 年齡范圍:1~12歲,年齡平均(6.28±3.36)歲,病程在4~15 d之間,病程平均為(8.62±3.19)d;對(duì)照組61例,29例男以及32例女,年齡范圍:1~12歲,年齡平均(6.01±3.50)歲,病程在4~14 d之間,病程平均為(8.05±2.64)d。研究經(jīng)醫(yī)院倫理委員會(huì)批準(zhǔn),且經(jīng)患兒家長(zhǎng)知情同意。全部患兒均除外伴有免疫系統(tǒng)疾病、惡性腫瘤、肝腎功能障礙等。兩組年齡、性別、病程差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05)。