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    綜合干預(yù)治療對(duì)重型-地中海貧血青春期女性生長(zhǎng)發(fā)育的效果觀察

    2017-10-09 08:29:04魏苗苗黃曉東高志娟陳國(guó)華
    關(guān)鍵詞:高志惠州市苗苗

    鄭 虹 丁 鳳 魏苗苗 張 旸 黃曉東 高志娟 陳國(guó)華

    廣東省惠州市第一人民醫(yī)院(516000)

    ·臨床分析·

    鄭 虹 丁 鳳 魏苗苗 張 旸 黃曉東 高志娟 陳國(guó)華

    廣東省惠州市第一人民醫(yī)院(516000)

    1 材料與方法

    1.1一般資料

    1.2數(shù)據(jù)獲取及干預(yù)方法

    1.3儀器與試劑

    LH、FSH、E2測(cè)定采用美國(guó) Abbott 公司的 I-2000 發(fā)光免疫分析儀及配套試劑,嚴(yán)格按照說明書進(jìn)行操作。超聲診斷采用美國(guó) Voluson E8彩超儀、日本東芝NemioMX超聲診斷儀。

    1.4統(tǒng)計(jì)學(xué)分析

    2 結(jié)果

    2.1各組對(duì)象治療前后臨床指證測(cè)定比較

    表1 各組研究對(duì)象治療前后臨床指證比較

    *與對(duì)照組比較P<0.05

    2.2各組對(duì)象治療前后血中性激素比較

    2.3各組對(duì)象治療前后性腺發(fā)育變化比較

    表2 各組研究對(duì)象治療前后血清生殖激素水平比較

    *與對(duì)照組比較P<0.05

    表3 各組研究對(duì)象治療前后性腺發(fā)育情況比較

    *與對(duì)照組比較P<0.05

    3 討論

    3.1重型地貧的相關(guān)研究狀況

    3.2目前重型地貧的治療方法

    3.3本研究結(jié)果發(fā)現(xiàn)

    [1] Muncie HL Jr,Campbell J.Alpha and beta thalassemia[J].Am FamPhysician, 2009, 80(4):339-344.

    [2] De Sanctis V, A.Eleftheriou, C.Malaventura.Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF) [J].Pediatr Endocrinol Rev, 2004, 2 Suppl 2:249-255.

    [3] Moayeri H., Z.Oloomi.Prevalence of growth and puberty failure with respect to growth hormone and gonadotropins secretion in beta-thalassemia major [J].Arch Iran Med, 2006, 9(4):329-334.

    [4] 陸時(shí)運(yùn), 周仲昊, 王晨, 等.去鐵胺治療長(zhǎng)期輸血所致鐵過載的療效觀察[J].隋床醫(yī)藥實(shí)踐, 2011, 20 (2):110-112.

    [5] Belhoul,Bakir ML,et al.Prevalence of iron overload complications among patients with b-thalassemia major treated at Dubai Thalassemia Centre[J].Ann Saudi Med.2013, 33(1):18-21.

    [6] Yin XL,Wu ZK, He YY,et al.Treatment and complications of thalassemia major in Gangxi,Southern China[J].Pediatr Blood Cancer 2011,57(7):1174-1178.

    [8] 王燕燕, 李曉輝, 徐西華.地中海貧血診治進(jìn)展與我國(guó)現(xiàn)狀[J].中國(guó)實(shí)用兒科雜志,2013, 28 (6) : 473-476.

    [9] Al-Rimawi HS,Jallad MF,Amarin ZO,et al.Hypoth alamic-pituitarygonadal function in adolescent females with beta-thalassemia major [J].Int JGyneco bstet,2005, 1(90):44-47.

    [10] Karamifarh, Shahriarim, Et A.L Amirhakimigh.Failure of puberty and linear growth in beta- thalassemia major[J].Turk Haematol, 2005, 22(2):65-69.

    [11] Borgna-Pignatri C, Rugoloeto S, De StefanoP, et al.Survival and complications in patients with beta-thalassaemia major treated with transfusin and deferoxamine.Haematologila, 2004,89(10):1187-1193.

    [12] 張新華, 黃有文.血液病診斷及療效標(biāo)準(zhǔn)//張之南,沈梯,主編.血液病診斷與療效標(biāo)準(zhǔn).3版.北京:科學(xué)技術(shù)出版社,2007:29-34.

    [13] De Sanctis V.Growth and puberty and its management in thalassaemiac[J].Horm Res,2007,58(Suppl 1):72-79.

    [14] Heshmat Moayeri,Zohreh Oloomi.Prevalence of Growth and Puberty Failure with Respect to Growth Hormone and Gonadotropins Secretion in Beta-Thalassemia Major[J].Arch Iran Med,2006,9(4):331-333.

    [15] C Roth A, Pekrun M, Bartz H, et al.Short stature and failure of pubertal development in thalassasemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion[J].Eur J Pediatr,1997,156:778-781.

    [16] 李輝, 季成, 葉宗南, 等.2009年中國(guó)0-18歲兒童身高、體重的標(biāo)準(zhǔn)化生長(zhǎng)曲線.中華兒科雜志[J] .2009, 47 (7):487-492.

    [17] Pan HF, Long GF, Li Q, et al.Current status ofthalassemia in minority populations in Gangxi, China[J].Clin Genet,2007,71 (5):419-426.

    [20] Shander A, Sazam a K.C finical consequences of iron overload from chronic red blood cell transfusions,its diagnosis,and its management by chelation therapy.Transfusion, 2010, 50(5): 1144-1155.

    [21] Taksande A,Prabhu S,Venkatesh S.Cardiovascular aspect of Beta thalassemia.Cardiovasc Hematol Agents Med Chem[J].2012 Mar 1;10(1):25-30.

    [22] Thalassemia.International Federation:Guidelines for the clinical management of thalassemia 2nd edition.2010.

    [24] 吳學(xué)東, 井遠(yuǎn)方, 溫建蕓, 等.造血干細(xì)胞移植治療地中海貧血[J].中國(guó)組織工程研究,2012, 6 (23):4339 -4348.

    [25] Angelucci E .Hematopoietic stem cell transplantation in thalassemia[J] .Hematology Am Soc Hematol Educ Program, 2010, 456 -462.

    [26] Schrier SL, Angehicei E .New strategies in the treatment of the thalassemias [J].Annu Rev Med, 2005,56: 157-171.

    [責(zé)任編輯:董 琳]

    ZHENG Hong, DING Feng, WEI Miaomiao, ZHANG Yang, HUANG Xiaodong, GAO Zhijuan, CHEN Guohua

    TheFirstpeople’sHospitalofHuizhou,Guangdong, 516000

    10.3969/j.issn.1004-8189.2017.06.007

    廣東省惠州市科技計(jì)劃項(xiàng)目(2014Y042)

    2017-01-00

    2017-03-15

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