Frontal Absence Seizures: Clinical and EEG Analysis of Four Cases

Li-ling Dong, Qiang Lu, Yan Huang, and Xiang-qin Zhou*

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Frontal Absence Seizures: Clinical and EEG Analysis of Four Cases

Li-ling Dong, Qiang Lu, Yan Huang, and Xiang-qin Zhou*

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

frontal absence status epilepticus; secondary bilateral synchrony

Chin Med Sci J 2016; 31(4):254-257

CCORDING to the commission of International League Against Epilepsy (ILAE) in 1989, typical absence seizures are generalized seizures, characterized by transient impairment of cons- ciousness (TIC) and generalized >2.5 Hz spike and slow wave discharges in ictal EEG.1Absence seizures with focal onset have been reported occasionally, such as frontal, temporal or parieto-occipital origin.2-3Lagae4identified a subgroup of children with absence epilepsy as frontal absence, whose ictal electroencephalograms (EEGs) showed generalized spike and slow wave preceded by frontal discharge. We presented four cases of frontal absence, with one case of frontal absence status epilepticus in them. The differences between typical and frontal absence seizures in clinical context and EEG were discussed.

From July 2009 to Jan 2015, four patients were diagnosed with frontal absences in our department. The diagnosis was made according to the following: 1) clinically characterized by recurrent transient impairment of cons- ciousness; 2) the ictal EEG showed generalized >2.5 Hz spike and slow wave preceded by frontal discharges. Three were females and one was male, with age ranged from 5 to 42 (mean 18.0±16.4) years. The age of onset ranged from 1 month to 18 years (mean 7.5±7.7 years).

All patients underwent history taking, physical exami- nation, brain MRI and continuous video-EEG monitoring (VEEG). After administration of antiepileptic drugs (AEDs), they were all followed up for one year. The electro-clinical features were analyzed and compared with typical absence seizures.

The clinical information and EEG characteristics are summarized in Table 1. The first three cases were charac- terized by recurrent, brief episodes of staring, behavior and speech arrest. Besides, the first and the third case had some motor signs during the ictus. The second case could walk at 18 months old and speak at 5 years old. The first two cases had retardation in intellectual development.

The fourth case was a prolonged absence seizure. Seizure semiology usually started with palpitation. She complained of limb weakness, but she could lift her arms and legs on command. Soon after, she showed a slowness of behavior, accompanied by staring, blinking, smacking, fumbling and involuntary movements of limbs. During the ictus, she could not speak most of the time, but she could follow simple instructions on repeated requests. The episode could last several days and recurred several times a month. If diazepam was given, the episode could be terminated in half an hour. Afterwards, she could only recollect what had happened in the first a few minutes. The interictal and ictal EEG of the fourth case are described in (Fig. 1).

All the four cases were resistant to AEDs treatment. In case 1, there was no improvement after the administration of Sodium Valproate, Clonazepam and Levetiracetam. As for case 2 and case 3, after oral administration of daily 1000 mg Sodium Valproate together with 2 mg Clonazepan, and daily 12 ml Sodium Valproate, respectively, remarkable reductions in seizure frequency were achieved after two or three months. The fourth case benefited from daily 800 mg Carbamazepine and 1000 mg Sodium Valproate. But none of them had attained a complete remission during 12 months of follow-up.

Lagae4has concluded some differences between typical and frontal absence group. The frontal absence group has more complex absences, which means staring associated with motor phenomena. Besides, high incidence of learning and behavioral problems, poor response to standard treatment and worse prognosis have been obser- ved in frontal absence group. In EEG, more patients of frontal absence group have background slowing and inter- ictal isolated frontal spikes than those in typical absence group, who usually have normal background and interictal single or short-range generalized 2.5 Hz-4 Hz spike and slow wave.4-6

In this study, the delayed intellectual development in first two cases and the resistance to standard AEDs treat- ment in all the four cases were consistent with Lagae’s findings.4In addition, compared with childhood absence epilepsy which occurs in otherwise normal children of school age (peak at 6-7 years),1both case 1 and case 3 had relatively earlier age of onset, and the episodes occurred as frequent as up to 30 events a day, which was in accordance with the clustering feature of frontal lobe epilepsy.

The fourth case was diagnosed as frontal absence status epilepticus (SE). Compared with typical absence SE which usually occurs in patients with idiopathic generalized epilepsy as reported,7-8she has mild impairment of consciousness and long duration of episode. Aphasia is prominent during the ictus, which is common in frontal lobe epilepsy. Carbamazepine combined with Sodium Valproate was effective in seizure control in this case, which supported the diagnosis of focal onset absence SE.

Table 1. Summary of clinical data of the four cases

yrs: years old; TIC: transient impairment of consciousness; AEDs: antiepileptic drugs; EEGs: electroencephalograms; * Preceding bilateral, symmetrical and synchronous discharge.

Figure 1. EEG of the case 4. A. Interictal EEG: Intermittent high amplitude 3-4 Hz spike and slow wave in bilateral frontal and central leads with right-sided predominance, under a background of 8 HZ α wave.B. Ictal EEG when the abnormal epileptic discharge just started, showing frequent high amplitude 3-4 Hz spike and slow wave in bilateral frontal and central regions, which was prevalent in the right side. The patient had no clinical symptoms at this moment. C. EEG of 19 minutes after the initiation of abnormal epileptic discharge, showing high amplitude 3-4 Hz spike and slow wave, prominent in bilateral frontal and central regions. The patient began to complain of palpitation and limb weakness, accompanied by automatisms and slow reaction.D. EEG of 26 minutes after the initiation of abnormal epileptic discharge, the focal onset abnormal discharge was followed by bilateral, symmetrical and synchronous high amplitude 3Hz spike and slow wave. The patient was not able to recall what had happened during this period. E. EEG of 6 hours after complete remission of clinical symptoms, showing intermittent bilateral synchronous high amp- litude 5 Hz θ wave. The generalized epileptiform discharges gradually subsided. She could move and speak as usual at this time.

The ictal EEGs in these cases showed secondary generalized 3-3.5 Hz spike and slow wave preceded by epileptic discharge in frontal regions; the interictal EEGs showed focal abnormality in frontal leads. The EEG distur- bances verified the diagnosis of focal onset absence seizures originating from frontal lobes, instead of generalized absence seizures.

Frontal absence is supposed to be related to secondary bilateral synchrony (SBS), described initially by Tukel and Jasper.9The epileptic discharge arises from frontal cortices and rapidly spreads to bilateral hemispheres through corpus callosum. Besides, SBS can also arise from temporal, parietal, and occipital regions. The thalamus may play a role in secondary bilateral synchronous discharges.9-11

In conclusion, frontal absences differ from typical absence seizures in clinical context, EEG, response to AEDs and prognosis. To thorough understand differences between typical and focal onset absence seizures might be meaning- ful in their surgical and pharmacological treatment. Electrode implantation should be considered when it is crucial to identify the source of absence seizures in the treatment。

1. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League against Epilepsy. Epilepsia 1989; 30:389-99.

2. Lombroso CT. Consistent EEG focalities detected in subjects with primary generalized epilepsies monitored for two decades. Epilepsia 1997; 38:797-812.

3. Tezer FI, Dericioglu N, Saygi S. Generalized spike-wave discharges with focal onset in a patient with head trauma and diffuse cerebral lesions: a case report with EEG and cranial MRI findings. Clin EEG Neurosci 2004; 35:151-7.

4. Lagae L, Pauwels J, Monté CP, et al. Frontal absences in children. Eur J Paediatr Neurol 2001; 5:243-51.

5. Joci?-Jakubi B, Jovanovi? M, Jankovi? DS, et al. Frontal-onset absences in children: associated with worse outcome? A replication study. Seizure 2009; 18:275-8.

6. Yang T, Luo C, Li Q, et al. Altered resting-state connectivity during interictal generalized spike-wave discharges in drug-na?ve childhood absence epilepsy. Hum Brain Mapp 2013; 34:1761-7.

7. Shorvon S, Walker M. Status epilepticus in idiopathic generalized epilepsy. Epilepsia 2005; 46 Suppl 9:73-9.

8. Dulac O, Takahashi T. Status epilepticus. Handb Clin Neurol 2013; 111:681-9.

9. Tukel K, Jasper H. The electroencephalogram in parasagittal lesions. Electroencephalogr Clin Neurophysiol 1952; 4: 481-94.

10. Chevrie JJ, Specola N, Aicardi J. Secondary bilateral synchrony in unilateral pial angiomatosis: successful surgical treatment. J Neurol Neurosurg Psychiatry 1988; 51:663-70.

11. Kanemura H, Sano F, Sugita K, et al. Ictal SPECT of thalamocortical coupling in a patient with frontal absence. Neuropediatrics 2011; 42:200-3.

for publication March 16, 2016.

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