“生物膜形態(tài)發(fā)生及維持的分子機(jī)制”立項(xiàng)報告

胡俊杰 張渺

摘 要：內(nèi)質(zhì)網(wǎng)是一個在細(xì)胞內(nèi)的普遍存在的生物膜系統(tǒng)，聯(lián)系了細(xì)胞質(zhì)、細(xì)胞核以及細(xì)胞膜等重要細(xì)胞結(jié)構(gòu)。內(nèi)質(zhì)網(wǎng)承擔(dān)了膜蛋白和分泌性蛋白的轉(zhuǎn)錄、折疊、修飾和轉(zhuǎn)運(yùn)，同時也是蛋白質(zhì)質(zhì)量的監(jiān)控點(diǎn)。它還具有糖類脂類合成、鈣調(diào)控和毒素降解的重要功能。內(nèi)質(zhì)網(wǎng)功能的紊亂能夠?qū)е绿悄虿〉却x疾病，以及多種神經(jīng)退行性疾病。由于形態(tài)的多樣性及功能的重要性，內(nèi)質(zhì)網(wǎng)成為研究生物膜結(jié)構(gòu)與功能的首選目標(biāo)，對內(nèi)質(zhì)網(wǎng)結(jié)構(gòu)與功能的研究與攻克重大人類疾病休戚相關(guān)，也是膜生物學(xué)國際科研的前沿。我們將以內(nèi)質(zhì)網(wǎng)的結(jié)構(gòu)為重點(diǎn)，系統(tǒng)研究細(xì)胞內(nèi)膜精細(xì)結(jié)構(gòu)形成和維持的關(guān)鍵機(jī)制，并深入探索膜結(jié)構(gòu)融合的機(jī)制，最終為闡述相關(guān)的重要細(xì)胞功能提供新的理論基礎(chǔ)。

關(guān)鍵詞：內(nèi)質(zhì)網(wǎng) 成管膜蛋白 膜融合

"Molecular Mechanism for Biomembrane Formation and Maintainance"/Project Report

Hu Junjie Zhang Miao

（Nankai University）

Abstract：The endoplasmic reticulum （ER） is an intracellular membrane system existed throughout the cytoplasm of cells. It forms connections between the cytoplasm， nucleus， and other important cellular membrane structures. The ER is not only required for the transcription， folding， modification and transport of the membrane proteins and secretory proteins， but also responsible for protein quality control. At the meantime it has important functions including synthesis of carbohydrate and lipid， calcium regulation and toxin degradation. The disorders of Endoplasmic reticulum function can result in several metabolic diseases like diabetes， and various neurodegenerative diseases. Given the structurally diversity and functionally importance of the endoplasmic reticulum， it became the concentration and leading edge of the biological membrane structure and function research， which is closely related to overcoming the major human diseases. We will focus on the structure of the endoplasmic reticulum， and systematically study the key mechanisms of intracellular membrane formation， maintenance， and fusion. Ultimately our study may provide new theoretical foundation for ER-related important cellular functions.

Key Words：Endoplasmic reticulum；Tubule-shaping proteins；Homotypic fusion

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