養(yǎng)陰活血泄?jié)岱街委熢缙谔悄虿∧I病的效果與安全性觀察

丁云東

[摘要] 目的 觀察采用養(yǎng)陰活血泄?jié)岱街委熢缙谔悄虿∧I病的臨床療效。 方法 回顧性分析76例早期糖尿病腎病患者資料，根據(jù)治療方法分為治療組（45例）和對(duì)照組（31例），均給予控制飲食、血糖、適量運(yùn)動(dòng)等糖尿病基礎(chǔ)治療，對(duì)照組采用西醫(yī)常規(guī)治療，并根據(jù)病情使用降糖藥，在此基礎(chǔ)上，治療組加用養(yǎng)陰活血泄?jié)嶂兴幏絼?，治療周期?2周。觀察兩組治療前后的實(shí)驗(yàn)室檢查指標(biāo)及不良反應(yīng)。 結(jié)果 治療12周后，兩組治療后的各主要指標(biāo)（FCG、HbAlC、TG、LDL-C、mAlb、UAER、hs-CRP、Cys C）均較治療前有明顯改善，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組治療后的各值較對(duì)照組治療后改善更明顯，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。 結(jié)論 養(yǎng)陰活血泄?jié)岱街委熢缙谔悄虿∧I病能有效改善各主要實(shí)驗(yàn)指標(biāo)值，具有較好的臨床療效，值得臨床運(yùn)用推廣。

[關(guān)鍵詞] 早期糖尿病腎??；養(yǎng)陰活血泄?jié)岱?；中藥；安全?/p>

[中圖分類號(hào)] R277.5 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 2095-0616（2015）17-19-04

Observation of clinical efficacy and safety of treatment with Yangyinhuoxuexiezhuo Fang on early diabetic nephropathy

DING Yundong

Guyuetao Studio，the TCM Hospital of Liaocheng City，Liaocheng 252000，China

[Abstract] Objective To observe the clinical efficacy and safety of treatment with Yangyin Huoxue Xiezhuo Fang on early diabetic nephropathy. Methods 76 patients with early diabetic nephropathy were divided into treatment group（45 cases）and control group（31 cases）follow the treatment methods retrospectively，and basic treatments for diabetes like controlling diet and blood glucose，exercising moderately were conducted on all patients；the control group used the conventional western medicine treatment，and hypoglycemic agents was used according to the disease，on that basis，the treatment group was given Yangyin Huoxue Xiezhuo Fang，and the treatment lasted for 12 weeks.The laboratory parameters before and after treatment，and adverse events were compared. Results After 12 weeks of treatment，the experimental index value（FCG、HbAlC、TG、LDL-C、mAlb、UAER、hs-CRP、Cys C）in both control group and treatment group were obviously improved comparing with that before treatment（P<0.05）.The value in treatment group presented a better improvement than that in the control group after treatment（P<0.05）. Conclusion Yangyin Huoxue Xiezhuo Fang on early diabetic nephropathy can effectively control the experimental index value， and has a good clinical efficacy that it is worth widely used in the clinic.

[Key words] Early diabetic nephropathy；Yangyin Huoxue Xiezhuo Fang；Traditional Chinese medicine；Safety

糖尿病腎?。╠iabetic nephropathy，DN）是糖尿病最常見、最嚴(yán)重的慢性并發(fā)癥之一，是代謝異常導(dǎo)致的腎小球硬化癥[1]，也是目前導(dǎo)致腎功能衰竭的重要原因之一，甚至有國(guó)外研究認(rèn)為DN已成為終末期腎病的首要原因。而在我國(guó)DN也已成為導(dǎo)致慢性腎功能衰竭的第3大原因[2]。研究發(fā)現(xiàn)控制尿微量蛋白有助于延緩DN的病程，因此，減少尿微量蛋白的排泄對(duì)早期DN的治療在臨床上顯得尤為重要。目前西醫(yī)對(duì)本病缺乏特效藥物，本研究在西醫(yī)常規(guī)治療基礎(chǔ)上加用養(yǎng)陰活血泄?jié)岱街委熢缙贒N，療效滿意，現(xiàn)報(bào)道如下。

1 資料與方法

1.1 一般資料

所有患者均來(lái)自我院2014年1月～2015年1月住院及門診病例，符合1999年WHO對(duì)DM的診斷標(biāo)準(zhǔn)及分型[3]。按mogensenDN分期標(biāo)準(zhǔn)[4]，診斷為DN Ⅲ期，即微量蛋白尿期，尿蛋白排出率（UAER）20～200μg/min（或>30mg/24h），至少檢查2次，持續(xù)3個(gè)月；血脂異常，血清甘油三酯（TG）≥2.2mmol/L，血清總膽固醇（TC）≥4.5mmol/L；血壓正?；蛘咻p度高血壓（血壓均為≤140/90mm Hg）；血肌酐（Scr）<112.3μmol/L。排除嚴(yán)重的肝、心及造