• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    A Meta-Analysis of Treating Radiation Proctitis by Retention Enema with Integrated Traditional Chinese and Western Medicine

    2020-04-19 07:38:24LIUJiajia劉佳佳XUEMeiping薛美平WANGBoWANGXixing王晞星
    關(guān)鍵詞:直腸炎粘膜佳佳

    LIU Jia-jia (劉佳佳), XUE Mei-ping (薛美平), WANG Bo (王 博), WANG Xi-xing (王晞星)

    1. Graduate School, Shanxi University of Chinese Medicine, Taiyuan 030000, China

    2. Oncology Department, Shanxi Traditional Chinese Medicine Hospital, Taiyuan 030000, China

    3. Graduate School, Shanxi Medical University, Taiyuan 030000, China

    ABSTRACT Objective:To systematically and objectively evaluate clinical efficacy of retention enema with integrated traditional Chinese and western medicine on radiation proctitis (RP). Methods:CNKI, WANFANG,VIP, CMB and foreign language databases like Embase, Central and Medline were searched. Search dates were from establishment of the databases until May 2020. Randomized controlled trials (RCTs) of retention enema with integrated traditional Chinese and western medicine for RP were retrieved. Two system reviewers selected literature materials, extracted literature data, and evaluated the quality of the literatures.RevMan 5.3 software was used for data analysis. Results:A total of 12 studies were included, including 941 patients. Meta-analysis results showed: Clinical efficacy in the retention enema group with integrated traditional Chinese and western medicine was better than that in the simple western medicine enema or blank enema group (OR=5.96, 95% CI [5.50, 14.29], P<0.000 01). Improvement of abdominal pain in the retention enema group with integrated traditional Chinese and western medicine was better than that in the control group (MD=-0.57, 95% CI [-0.72, -0.42], P<0.000 01). Treatment for hematochezia in the retention enema group with integrated traditional Chinese and western medicine was better than that in the control group (MD=-0.55, 95% CI [-0.69, -0.42], P<0.000 01). Improvement of diarrhea in the retention enema group with integrated traditional Chinese and western medicine was better than that in the control group(MD=-0.69, 95% CI [-0.91, -0.48], P<0.000 01). KPS scores in the retention enema group with integrated traditional Chinese and western medicine were better than those in the control group (MD=11.91, 95%CI [3.81, 20.01], P<0.000 01). Conclusion:Clinical efficacy of retention enema with integrated traditional Chinese and western medicine on RP is better than simple western medicine enema or blank enema. Due to the low quality of the included clinical literatures, it is necessary to carry out more deliberate, detailed,high-quality, randomized, double-blind, and multi-center RCTs in order to give more powerful demonstration on its clinical efficacy on RP.

    KEYWORDS A Meta-analysis; Radiation proctitis; Integrated traditional Chinese and western medicine;Retention enema

    Radiation proctitis (RP) is a rectal mucosal injury caused by radiotherapy for malignant pelvic tumors[1]. It clinically manifests as increased frequency of bowel movements, abdominal pain and discomfort, ungratifying diarrhea, a feeling of heavy sinking during defecation, blood-stained stools, etc.. It can even cause rectal stenosis,rectal ulcer, anorectal fistula, etc. Studies have shown that such adverse reactions can occur when the total amount of radiotherapy received by a patient reaches 30 Gy. If the total amount of radiation reaches 50-70 Gy, the incidence of adverse reactions will reach 70%[1]. For RP,western medicine mainly focus on symptomatic treatment such as anti-inflammation, antibiotics,probiotics, antioxidant antidiarrheal agents,somatostatin, etc.[2]. But it has disadvantages like easy to relapse, severe adverse reactions,not suitable for long-term use, and unsatisfactory clinical efficacy. Traditional Chinese medicine(TCM) include oral Chinese materia medica and preparations, Chinese materia medica enema, sitz bath, acupuncture and moxibustion etc. But there are also problems such as diverse prescriptions based on syndrome differentiation and inconsistent efficacy standards.Consensus on Diagnosis and Treatment for Radiation Proctitis(《放射性直腸炎(腸澼)診療共識(shí)》)[3]recommends that "anal dripping retention enema" is the best therapeutic plan for RP. Therefore, this study systematically evaluated clinical efficacy of retention enema on RP with integrated traditional Chinese and western medicine in order to provide reference for future clinical study and clinical application.

    MATERIALS AND METHODS

    Selection of Literatures

    Inclusion criteria

    ① Study design methods: The trial design was in accordance with the clinical randomized controlled method. Any mention of "random entry"in the literature, regardless of whether blinding and allocation concealment were mentioned or not, it was included. ② Study objects: RP patients. Age,gender, region and race were not limited. ③ Control measures: Western medicine/blank retention enema. ④ Intervention measures: Retention enema(with integrated traditional Chinese and western medicine). ⑤ Evaluation indexes of study results:Effects of enema and symptom scores. ⑥ Available raw data of the literature.

    Exclusion criteria

    Literatures met one or more of the following were excluded. ① Abstracts, conference papers,letters, and periodical literatures with data errors or missing. ② Multiple submissions. ③ The full text was unknown. ④ Non-Chinese and English literatures. ⑤ Categories of research progress,case sharing, conference guidelines and basic study. ⑥ Papers without original data or papers whose data could not be used. ⑦ Incomplete randomized controlled trial (RCT) studies, including quasi-randomized controlled studies (e.g. studies with allocation plans based on dates of visits or ID tail numbers) and studies lacking comparison on efficacy before and after in the control group. ⑧Those without evaluation indexes of relevant study results. ⑨ Retrospective studies. ⑩ Missing or incomplete efficacy evaluation standards. Without description on ways of administration.

    Literature Retrieval Strategies

    Relevant requirements and guidelines in the work manual of the international medical center The Cochrane Collaboration were followed. Computers were used to search CNKI, Wanfang, VIP, CBM,Embase, Central and Medline. Search dates were stopped by May 2020. Chinese and English were search languages. Chinese search terms included"放射性直腸炎", "放射性腸炎", "放射性直腸粘膜損傷", "放射性直腸", "腸澼", "中西醫(yī)結(jié)合", "中西醫(yī)", "保留灌腸" and "灌腸". English search terms included "radiation enteritis" "RE" "radiation proctitis""combination of traditional Chinese and Western medicine" "Integrated Chinese and Western Medicine" and "Enema". Combination of subject terms and freed terms was applied for searching, and references of the included literatures were tracked.

    Literature Screening

    EndNote X9 file management software was applied to remove repetitive literatures. Then,2 system reviewers read titles and abstracts to screen literatures in strict accordance with the above inclusion and exclusion criteria to remove unqualified literatures. By reading full texts carefully to clarify the final included ones. When there were conflicts or disagreements, they were negotiated by the 2 or with the third system reviewer. When having incomprehension during literature screening, original authors could be contacted. If the original authors were unavailable, the literatures would be excluded.

    Data Extraction

    Data extraction included basic situations of studies, study methods, sample sizes, outcome indicators, etc. Two system reviewers independently screened literatures based on the above criteria, and at the same time performed quality evaluation and cross-checked the results. In case of disagreements,the third researcher would participate in discussions and make decisions through consultation. At the same time, the authors of the literatures would be contacted to clarify the reliability of study related information.

    Quality Evaluation

    Standards inCochrane Review Handbook 5.0were followed to evaluate the quality of included literatures. The evaluation mainly focused on the following aspects. ① Whether random grouping was used in the clinical trial. ② Whether allocation concealment was performed in the clinical trial. ③Whether blinding was used to avoid implementation bias and measurement bias. ④ Whether study outcome indicators were complete. ⑤ Whether the study outcome indicators were selectively reported.⑥ Whether there was bias caused by other factors.Risk assessment on each item was based on specific conditions of included studies. Two system reviewers independently extracted relevant data and conducted corresponding data analysis. In addition,after extracting the data, they were cross-checked. If there were conflicts or disagreements, they could be resolved through discussion and communication or inviting a third person to determine. When extracting the data, if it was found that there was a lack of data required for this study, the original author was contacted in order to complete the data.

    Statistical Analysis

    Meta-analysis was performed by using RevMan 5.3 software. When testing whether there was heterogeneity among the included literatures,P>0.1 was set as the test criterion. IfP>0.1, it meant that the heterogeneity among the included literatures was small and they could be amalgamated. In this case, the fixed effect model was used. On the contrary, the random effect model was selected.The heterogeneity test was performed by usingI2quantitative analysis, andI2>50% was considered to be heterogeneous. In this case, the random effect model was used, otherwise the fixed effect model was selected. Analysis on efficacy indicators was conducted by using odds ratios (OR), and a 95% confidence interval (CI) was given. Existence of potential publication bias was analyzed with an"inverted funnel" plot.

    RESULTS

    Literature Screening Results

    A total of 236 literatures were retrieved in the initial search, and 152 literatures were obtained after removing duplicates. After reading the titles and abstracts of the literatures, 88 literatures were screened out, and then a second screening was performed on the basis of the full text reading.Literatures with clinical study trial designs that were not in accordance with the inclusion and exclusion criteria were screened out, and 12 literatures were included, in which the random grouping method was applied in their trial designs, and the literatures were all from China. Detailed literature screening steps and the final included studies are shown in Figure 1.A total of 941 patients were included, including 488 in the trial group and 453 in the control group. Basic characteristics of the included literatures are shown in Table 1.

    Figure 1. Literature Retrieval Flow Chart

    Evaluation on Literature Quality

    A total of 12 literatures were finally included in this study. Standards in the Cochrane ReviewHandbook 5.0 were followed to evaluate the quality of the included literatures. ① The random grouping method: In the included literatures, the random number table method was used for study grouping in 2 clinical trials, grouping based on the order of visits was used in 1 clinical study, and the remaining 9 clinical study literatures only mentioned the use of random grouping, without clearly explaining specific grouping methods. ② The allocation concealment scheme: It was mentioned in none of the studies. ③Blinding: It was mentioned in none of the studies.④ Outcome data: All study outcome data were complete. Selective reporting: Selective reporting of all the studies was unclear. ⑤ Other bias: Bias caused by other factors in all the studies was unclear.The quality evaluation is shown in Figure 2 and Figure 3.

    Table 1. Basic Characteristics of Included Literatures

    (Continued Table 1)

    Results of Meta-Analysis

    Clinical efficacy

    Figure 2. Quality Evaluation on Included Literatures

    Figure 3. Quality Evaluation on Included Literatures

    The 12 clinical study literatures included in this paper all reported clinical efficacy of retention enema for RP with integrated traditional Chinese and western medicine. The total sample size was 941 cases, of which 488 cases were included in the trial group and 453 cases in the control group. Heterogeneity analysis showed that there was no heterogeneity among the results of the clinical study trials (P=0.82,I2=0%), and they could be amalgamated, so the fixed effect model was chosen for data analysis. Results of Meta-analysis showed that in terms of the clinical efficacy on RP, the comparative study between the trial group and the control group was statistically significant (P<0.000 01). The result of combined test analysis wasZ=8.96, and the combined effect size and 95% CI of the clinical efficacy were (OR=5.96,95% CI [5.50, 14.29]), indicating that clinical efficacy of retention enema with integrated traditional Chinese and western medicine on RP is better than that of simple western medicine enema or blank enema. The results are shown in Figure 4.

    An "inverted funnel" plot with OR as the abscissa and log[OR] as the ordinate was drawn.Existence of publication bias of the 12 finally included clinical study literatures was analyzed.Results are showed in Figure 5 that it is symmetrical,indicating less publication bias.

    Figure 5. Funnel Plot of Publication Bias

    Figure 4. Forest Map of Improvement of Clinical Efficacy

    Figure 6. Forest Map of Improvement of Abdominal Pain

    Figure 7. Forest Map of Improvement of Hematochezia

    TCM symptoms

    Abdominal pain: Among the 12 literatures included in this study, there were 3 literatures comparing the symptom of abdominal pain. The heterogeneity analysis showed that there was no statistical heterogeneity among the clinical study trial results of the 3 literatures (P=0.6,I2=0%). That is, homogeneity of the included clinical studies was good, so the fixed effect model was used for data analysis. The results of Meta-analysis showed that the comparative study between the trial group and the control group show a statistically significant in difference improving the symptom of abdominal pain in RP (P<0.000 01). The result of combined test analysis wasZ=7.60, the MD value was the combined statistical magnitude, and the combined effect size and 95% CI of the data were (MD=-0.57, 95% CI [-0.72, -0.42]). It shows that retention enema with integrated traditional Chinese and western medicine for RP is better than simple western medicine enema or blank enema in alleviating and improving abdominal pain in RP. The results are shown in Figure 6.

    Hematochezia: Among the 12 literatures included in this study, there were 3 literatures comparing the symptom of hematochezia. The heterogeneity analysis showed that there was no statistical heterogeneity among the clinical study trial results of the 3 literatures (P=0.65,I2=0%), indicating that homogeneity of the included studies was good,so the fixed effect model was used. The results of the Meta-analysis showed that in correcting and improving the symptom of hematochezia in RP patients, comparison on efficacy in the trial group and the control group was statistically significant(P<0.000 01). The result of combined test analysis wasZ=8.15, the MD value was the combined statistical magnitude, and the combined effect size and the 95% CI of the data were (MD=-0.55,95% CI [-0.69, -0.42]). It shows that in correcting and improving the symptom of hematochezia,retention enema with integrated traditional Chinese and western medicine for RP has a better clinical efficacy. The results are shown in Figure 7.

    Diarrhea: In this study, there were 2 literatures comparing the symptom of diarrhea. The heterogeneity analysis showed that there was no statistical heterogeneity between the clinical study trial results of the 2 literatures (P=0.22,I2=32%), indicating that homogeneity of the included studies was good, so the fixed effect model was used. The results of the Meta-analysis showed that for the diarrhea symptom in RP, comparison on treatment methods between the trial group and the control group was statistically significant (P<0.000 01). The result of combined test analysis wasZ=6.41, the MD value was the combined statistical magnitude, and the combined effect size and the 95% CI of the data were (MD=-0.69,95% CI [-0.91, -0.48]). Therefore, for correction and improvement of diarrhea, the clinical efficacy of retention enema with integrated traditional Chinese and western medicine for RP is better than that of simple western medicine enema or blank enema.The results are shown in Figure 8.

    Figure 8. Forest Map of Improvement of Diarrhea

    Figure 9. Forest Map of KPS

    KPS

    KPS was compared in 3 of the 12 literatures included in this study. The heterogeneity analysis showed that there was statistical heterogeneity among the trial results (P=0.004,I2=98%), so the random effect model was used. The results of the meta analysis showed that for treating RP, KPS scores in the trial group and the control group were statistically significant (P<0.000 01). The result of combined test analysis wasZ=2.88, the MD value was the combined statistical magnitude, and the combined effect size and the 95% CI of the data were (MD=11.91, 95% CI [3.81, 20.01]). It indicates that retention enema with integrated traditional Chinese and western medicine for treating RP has statistical significance, compared to simple western medicine enema or blank enema. The results are shown in Figure 9.

    DISCUSSION

    RP has no corresponding records in ancient literatures. It is a disease caused by extensive use of radiotherapy technology in tumor treatment with its development. According to its relevant clinical symptoms, it can be classified into "dysentery","diarrhea" "hematochezia" "radiation proctitis"and so on in TCM. Chinese scholars believe that the basic pathogenesis of its occurrence is related to fire-heat-toxin pathogens, dampnessheat, stagnation of Qi (氣), radioactive rays,phlegm and blood stasis, spleen deficiency,etc. The onset is mostly caused by radiation damage to the rectal mucosa. At present, there are different opinions on the treatment of this disease, without consensus, and each treatment has distinct advantages and disadvantages. There are problems in TCM treatment for RP, such as syndrome differentiation, various prescriptions and inconsistent judgment criteria on clinical efficacy, so that there is no clear, unified and effective method for its treatment. Western medicine mainly treats RP with symptomatic treatments like anti-inflammatory,antibiotics, probiotics, antioxidant antidiarrheal agents, somatostatin, etc.[2]But it has disadvantages like easy to relapse, severe adverse reactions, not suitable for long-term use, and unsatisfactory clinical efficacy. Therefore, for the RP treatment, the latest study believes that efficacy of integrated traditional Chinese and western medicine is better. By retention enema, drugs can directly act on lesions of the rectal mucosa. Therefore, theConsensus on Diagnosis and Treatment for Radiation Proctitisrecommends that "anal dripping retention enema" is the best therapeutic plan for RP[3].

    In recent years, the incidence of tumors has been "constantly high". As a common treatment for tumors, radiotherapy will inevitably cause RP in patients undergoing pelvic radiotherapy. The occurrence of this disease will seriously affect the efficacy and quality of life in patients with tumors, and the various treatment methods for this disease are difficult to achieve significant clinical efficacy, and sometimes even backfire and have a counterproductive effect. In view of the lack of effective treatment methods, a number of relevant clinical studies have been carried out in recent years. According to the latest study, retention enema with integrated traditional Chinese and western medicine has obvious advantages. However, due to problems in the early studies, such as few cases enrolled in the groups, lack of comprehensive study content, imperfect study methods and so on, further study is necessary.

    Therefore, a method in evidence-based medicine was applied in this study to explore clinical efficacy of retention enema with integrated traditional Chinese and western medicine for RP. When comparing the retention enema with integrated traditional Chinese and western medicine with single western medicine or blank enema, it was found that the retention enema with integrated traditional Chinese and western medicine had better clinical efficacy. This treatment plan also had significant advantages in improving and correcting symptoms of diarrhea, abdominal pain, hematochezia, etc.In terms of KPS scores, when comparing the trial group with the control group, the study result is also statistically significant. The significance of this study result is that it not only provides certain evidencebased medical support for evaluation on the clinical efficacy of retention enema with integrated traditional Chinese and western medicine for RP, but also provides an idea and reference of diagnosis and treatment for clinicians during clinical diagnosis and treatment. Through literature collection, expansion of the study base and comprehensive analysis,efficacy of retention enema with integrated traditional Chinese and Western medicine was analyzed more accurately and efficiently from multiple angles.Supported by scientific data, necessity, rationality and high efficiency of retention enema treatment with integrated traditional Chinese and western medicine was also evaluated more accurately and objectively.However, this study also has its shortcomings.First of all, although a Chinese and English search was conducted, after many times of screening,the final clinical study literatures included were all Chinese literatures, which lacked a certain degree of comprehensiveness. The included literatures were generally of low quality in trial study methodology,and plans for allocation concealment and blinding were not mentioned. In terms of KPS data, there was statistical heterogeneity, which might be related to the small number of included clinical studies. Therefore,this study only conducted a preliminary systematic review on the retention enema with integrated traditional Chinese and western medicine for RP, in order to appeal to more and in-depth understandings,which need to be proved by more rigorous designed,high-quality and multi-center randomized double-blind clinical controlled trials.

    猜你喜歡
    直腸炎粘膜佳佳
    歡樂的歌
    韓捷治療潰瘍性直腸炎的經(jīng)驗(yàn)總結(jié)
    王晞星治療放射性直腸炎經(jīng)驗(yàn)
    南瓜燈
    宮頸癌放療后放射性直腸炎發(fā)生情況及其相關(guān)因素分析
    我的校園
    選擇
    基于嚴(yán)重?zé)齻剐菘藭r(shí)胃腸粘膜內(nèi)缺血的研究
    粘膜下陰道緊縮術(shù)矯正陰道松弛的護(hù)理
    粘膜下陰道緊縮術(shù)手術(shù)治療陰道松弛患者的護(hù)理
    欧美乱妇无乱码| 精品久久久久久,| 熟女人妻精品中文字幕| 亚洲国产色片| 亚洲国产精品合色在线| 亚洲最大成人手机在线| av天堂在线播放| 亚洲精品粉嫩美女一区| 免费无遮挡裸体视频| 99精品久久久久人妻精品| 中文字幕av成人在线电影| 一级黄片播放器| 亚洲真实伦在线观看| www.熟女人妻精品国产| 国产欧美日韩精品亚洲av| 岛国在线观看网站| 好男人在线观看高清免费视频| 久久亚洲精品不卡| 一级毛片高清免费大全| 十八禁人妻一区二区| 少妇人妻一区二区三区视频| 精品久久久久久久久久免费视频| 亚洲aⅴ乱码一区二区在线播放| 国产三级中文精品| 日韩欧美国产在线观看| 舔av片在线| 免费在线观看影片大全网站| svipshipincom国产片| 香蕉丝袜av| 老司机在亚洲福利影院| 99久久精品国产亚洲精品| 美女高潮喷水抽搐中文字幕| 成人永久免费在线观看视频| 国产欧美日韩一区二区精品| 黄色女人牲交| 久久精品亚洲精品国产色婷小说| 亚洲aⅴ乱码一区二区在线播放| 亚洲自拍偷在线| 日日夜夜操网爽| 亚洲成av人片免费观看| 最新中文字幕久久久久| 亚洲午夜理论影院| 麻豆国产av国片精品| 日本 av在线| 9191精品国产免费久久| 18禁黄网站禁片午夜丰满| 欧美黄色片欧美黄色片| 在线a可以看的网站| 久久国产精品人妻蜜桃| 亚洲七黄色美女视频| 国产视频一区二区在线看| 可以在线观看毛片的网站| 日本撒尿小便嘘嘘汇集6| 免费人成视频x8x8入口观看| 高清日韩中文字幕在线| 国产爱豆传媒在线观看| 欧美不卡视频在线免费观看| 国产久久久一区二区三区| 男插女下体视频免费在线播放| 九九热线精品视视频播放| 男人舔女人下体高潮全视频| 亚洲一区二区三区色噜噜| 国产亚洲精品av在线| 在线播放国产精品三级| 18禁黄网站禁片午夜丰满| 母亲3免费完整高清在线观看| 天堂动漫精品| 亚洲国产精品sss在线观看| 亚洲专区国产一区二区| 精品久久久久久久人妻蜜臀av| 成熟少妇高潮喷水视频| 亚洲欧美日韩高清专用| 女人十人毛片免费观看3o分钟| 天堂动漫精品| 中文字幕人成人乱码亚洲影| 两个人的视频大全免费| 两个人看的免费小视频| 老司机午夜福利在线观看视频| 男插女下体视频免费在线播放| 国内毛片毛片毛片毛片毛片| 国模一区二区三区四区视频| 丰满乱子伦码专区| 国产免费av片在线观看野外av| 国产av在哪里看| 久久国产精品影院| 国产精品亚洲美女久久久| 两个人看的免费小视频| 亚洲欧美精品综合久久99| 99在线视频只有这里精品首页| 欧美成人性av电影在线观看| 国产精品一区二区三区四区久久| 国产一区在线观看成人免费| 每晚都被弄得嗷嗷叫到高潮| 国语自产精品视频在线第100页| 真人做人爱边吃奶动态| tocl精华| 欧美成人性av电影在线观看| 久久久久久久午夜电影| 久久这里只有精品中国| 男人舔奶头视频| 国产99白浆流出| 国产精品乱码一区二三区的特点| 99热精品在线国产| 成人鲁丝片一二三区免费| 国产精品嫩草影院av在线观看 | 亚洲国产欧美人成| 久久久久久久久大av| 日韩成人在线观看一区二区三区| 国产精品亚洲一级av第二区| 日韩国内少妇激情av| 久久久久久久久中文| 国产aⅴ精品一区二区三区波| 成人鲁丝片一二三区免费| 操出白浆在线播放| 中国美女看黄片| 成人午夜高清在线视频| 欧美一区二区国产精品久久精品| 亚洲av美国av| 九九久久精品国产亚洲av麻豆| 在线视频色国产色| 亚洲精品亚洲一区二区| 亚洲中文字幕日韩| 一个人看的www免费观看视频| 熟妇人妻久久中文字幕3abv| 国内精品久久久久精免费| 日本在线视频免费播放| 两人在一起打扑克的视频| 中亚洲国语对白在线视频| 亚洲av一区综合| 叶爱在线成人免费视频播放| 亚洲av熟女| av在线天堂中文字幕| 亚洲av免费在线观看| 男女午夜视频在线观看| 日韩欧美 国产精品| 国产精品亚洲一级av第二区| 老熟妇乱子伦视频在线观看| 特级一级黄色大片| 韩国av一区二区三区四区| 真人做人爱边吃奶动态| 免费观看精品视频网站| 一本精品99久久精品77| 国产精品久久电影中文字幕| 久久精品国产99精品国产亚洲性色| 99热6这里只有精品| 可以在线观看的亚洲视频| 亚洲欧美日韩高清专用| 国产精华一区二区三区| 国模一区二区三区四区视频| 夜夜爽天天搞| 91在线精品国自产拍蜜月 | 成熟少妇高潮喷水视频| 国产单亲对白刺激| 性欧美人与动物交配| 非洲黑人性xxxx精品又粗又长| tocl精华| 日韩亚洲欧美综合| 成人无遮挡网站| tocl精华| 欧美成狂野欧美在线观看| www.www免费av| 成人无遮挡网站| 最后的刺客免费高清国语| 嫩草影院入口| 国产精品久久久久久人妻精品电影| 免费观看人在逋| 乱人视频在线观看| 在线播放无遮挡| 成人亚洲精品av一区二区| 非洲黑人性xxxx精品又粗又长| 黄色片一级片一级黄色片| 亚洲人成电影免费在线| 国产 一区 欧美 日韩| 伊人久久精品亚洲午夜| 成人国产综合亚洲| 一进一出抽搐gif免费好疼| 久久精品国产自在天天线| 国产国拍精品亚洲av在线观看 | 一本精品99久久精品77| 午夜福利在线观看免费完整高清在 | av欧美777| 白带黄色成豆腐渣| 99精品在免费线老司机午夜| 99精品在免费线老司机午夜| www国产在线视频色| 国产精品野战在线观看| 又黄又粗又硬又大视频| 日本免费一区二区三区高清不卡| 日韩 欧美 亚洲 中文字幕| 国产亚洲欧美在线一区二区| 99热只有精品国产| 亚洲熟妇中文字幕五十中出| 欧美又色又爽又黄视频| 亚洲最大成人中文| 国产 一区 欧美 日韩| 国产av麻豆久久久久久久| 日韩欧美在线二视频| 特大巨黑吊av在线直播| 国产aⅴ精品一区二区三区波| 亚洲精品亚洲一区二区| 桃红色精品国产亚洲av| 亚洲成a人片在线一区二区| 亚洲人成伊人成综合网2020| e午夜精品久久久久久久| 国产精品久久久久久久久免 | 亚洲av熟女| 亚洲五月天丁香| 久久午夜亚洲精品久久| 免费在线观看亚洲国产| 色av中文字幕| 国产在线精品亚洲第一网站| 性欧美人与动物交配| 在线播放国产精品三级| 老师上课跳d突然被开到最大视频 久久午夜综合久久蜜桃 | 国产高清有码在线观看视频| 日韩欧美精品免费久久 | 亚洲国产色片| aaaaa片日本免费| 美女高潮喷水抽搐中文字幕| 综合色av麻豆| 极品教师在线免费播放| 最近最新免费中文字幕在线| 国产淫片久久久久久久久 | 成人午夜高清在线视频| 男人的好看免费观看在线视频| 在线观看日韩欧美| 中出人妻视频一区二区| av黄色大香蕉| 久久久久久久久久黄片| АⅤ资源中文在线天堂| а√天堂www在线а√下载| 午夜精品在线福利| 99久国产av精品| 国产在线精品亚洲第一网站| 国产伦在线观看视频一区| 一个人免费在线观看的高清视频| 少妇裸体淫交视频免费看高清| 91久久精品国产一区二区成人 | 青草久久国产| 老司机午夜福利在线观看视频| 亚洲在线自拍视频| 免费看光身美女| 每晚都被弄得嗷嗷叫到高潮| 欧美bdsm另类| 有码 亚洲区| 久久天躁狠狠躁夜夜2o2o| 亚洲成人久久爱视频| 亚洲第一电影网av| 欧美最黄视频在线播放免费| 99久久九九国产精品国产免费| 日韩免费av在线播放| 日韩 欧美 亚洲 中文字幕| 哪里可以看免费的av片| 69av精品久久久久久| 亚洲成人久久爱视频| 亚洲国产精品久久男人天堂| 99久久精品一区二区三区| 国产精品1区2区在线观看.| 午夜福利在线在线| 国产主播在线观看一区二区| 久久久精品欧美日韩精品| 亚洲最大成人手机在线| 成熟少妇高潮喷水视频| 精品久久久久久久人妻蜜臀av| 三级男女做爰猛烈吃奶摸视频| av中文乱码字幕在线| 免费电影在线观看免费观看| 黄色视频,在线免费观看| 男人和女人高潮做爰伦理| 亚洲久久久久久中文字幕| 欧美高清成人免费视频www| 精品国产超薄肉色丝袜足j| 3wmmmm亚洲av在线观看| 欧美一区二区国产精品久久精品| 黄片大片在线免费观看| 久久久国产成人精品二区| 怎么达到女性高潮| 黄色成人免费大全| 色在线成人网| 久久久久久国产a免费观看| 高清毛片免费观看视频网站| 精品久久久久久久久久久久久| 日本熟妇午夜| 身体一侧抽搐| 精品国产美女av久久久久小说| 午夜亚洲福利在线播放| bbb黄色大片| 久久久精品大字幕| 免费无遮挡裸体视频| 2021天堂中文幕一二区在线观| 美女高潮喷水抽搐中文字幕| 夜夜爽天天搞| 亚洲精品456在线播放app | 18禁在线播放成人免费| 欧美日韩一级在线毛片| 两个人看的免费小视频| 精品福利观看| 精华霜和精华液先用哪个| 亚洲狠狠婷婷综合久久图片| 欧美色视频一区免费| 日韩欧美国产在线观看| 激情在线观看视频在线高清| 久久久久亚洲av毛片大全| 亚洲熟妇熟女久久| 久久久久国内视频| 午夜久久久久精精品| 在线a可以看的网站| 久久精品国产自在天天线| 啪啪无遮挡十八禁网站| 亚洲人成网站高清观看| ponron亚洲| 乱人视频在线观看| 日韩欧美国产在线观看| 日韩免费av在线播放| 一夜夜www| 免费在线观看亚洲国产| 国产精品久久久久久久久免 | 热99re8久久精品国产| 中出人妻视频一区二区| 无限看片的www在线观看| av在线蜜桃| 偷拍熟女少妇极品色| 国产亚洲欧美98| 免费看光身美女| 久久精品夜夜夜夜夜久久蜜豆| 天美传媒精品一区二区| 他把我摸到了高潮在线观看| 国产免费av片在线观看野外av| 岛国在线免费视频观看| 国产单亲对白刺激| 国产精品99久久久久久久久| 午夜影院日韩av| 亚洲性夜色夜夜综合| 欧美xxxx黑人xx丫x性爽| 精品久久久久久久毛片微露脸| 国产亚洲精品久久久com| 国产精品 欧美亚洲| 熟妇人妻久久中文字幕3abv| 在线观看av片永久免费下载| 国产三级在线视频| 女生性感内裤真人,穿戴方法视频| 国产精品嫩草影院av在线观看 | 久久久久久人人人人人| 亚洲精品国产精品久久久不卡| 亚洲成av人片免费观看| 欧美大码av| 国产精品99久久99久久久不卡| 久久久成人免费电影| 中亚洲国语对白在线视频| 可以在线观看毛片的网站| 两性午夜刺激爽爽歪歪视频在线观看| 国产三级在线视频| 国产精品女同一区二区软件 | eeuss影院久久| 亚洲av第一区精品v没综合| 亚洲第一欧美日韩一区二区三区| 伊人久久精品亚洲午夜| eeuss影院久久| 夜夜爽天天搞| 国产av一区在线观看免费| 欧美区成人在线视频| 午夜免费观看网址| 日本一二三区视频观看| 夜夜躁狠狠躁天天躁| 每晚都被弄得嗷嗷叫到高潮| 久久香蕉国产精品| 很黄的视频免费| 99久久99久久久精品蜜桃| 最好的美女福利视频网| 少妇裸体淫交视频免费看高清| 国产精品久久久久久久久免 | 国产精品 欧美亚洲| 在线观看66精品国产| 在线免费观看的www视频| 1024手机看黄色片| 日日摸夜夜添夜夜添小说| 国产精品影院久久| 我要搜黄色片| 一卡2卡三卡四卡精品乱码亚洲| 一个人看的www免费观看视频| 香蕉av资源在线| 久久久色成人| 国产欧美日韩精品一区二区| 久久久久亚洲av毛片大全| 亚洲av一区综合| 一卡2卡三卡四卡精品乱码亚洲| 亚洲专区国产一区二区| 亚洲精品色激情综合| 桃色一区二区三区在线观看| 一个人看视频在线观看www免费 | av女优亚洲男人天堂| 日日摸夜夜添夜夜添小说| 免费看a级黄色片| 亚洲aⅴ乱码一区二区在线播放| 尤物成人国产欧美一区二区三区| 日本黄大片高清| 亚洲无线在线观看| xxxwww97欧美| 欧美精品啪啪一区二区三区| 国产蜜桃级精品一区二区三区| 久久精品91无色码中文字幕| 夜夜躁狠狠躁天天躁| 亚洲av成人不卡在线观看播放网| 制服丝袜大香蕉在线| 成人亚洲精品av一区二区| 欧美区成人在线视频| 九色成人免费人妻av| 精品无人区乱码1区二区| 日本熟妇午夜| 亚洲激情在线av| 久99久视频精品免费| 中文字幕高清在线视频| 搡老岳熟女国产| 国产成人影院久久av| 99久久精品一区二区三区| 亚洲国产精品999在线| 久久精品91无色码中文字幕| 免费在线观看日本一区| 日本与韩国留学比较| 午夜福利在线观看吧| 国产精品电影一区二区三区| 亚洲成人精品中文字幕电影| 亚洲精华国产精华精| 看免费av毛片| 国产真实伦视频高清在线观看 | 亚洲中文字幕一区二区三区有码在线看| 成人特级av手机在线观看| 欧美成人免费av一区二区三区| 日本成人三级电影网站| 久久精品综合一区二区三区| 亚洲av不卡在线观看| 日本黄大片高清| 日韩欧美免费精品| 国产高清videossex| 成人国产一区最新在线观看| 亚洲aⅴ乱码一区二区在线播放| 夜夜夜夜夜久久久久| 国产精品乱码一区二三区的特点| 搡老岳熟女国产| 亚洲av免费高清在线观看| 亚洲一区二区三区不卡视频| 国产精品久久久久久精品电影| 午夜精品在线福利| 国产成+人综合+亚洲专区| 亚洲精品美女久久久久99蜜臀| 国产成人欧美在线观看| 午夜两性在线视频| 亚洲性夜色夜夜综合| 成人亚洲精品av一区二区| 麻豆久久精品国产亚洲av| 哪里可以看免费的av片| 久久草成人影院| 国产一级毛片七仙女欲春2| 床上黄色一级片| 午夜福利成人在线免费观看| 两个人的视频大全免费| 狠狠狠狠99中文字幕| 欧美一级a爱片免费观看看| 在线视频色国产色| 午夜福利在线观看吧| 午夜免费男女啪啪视频观看 | 在线视频色国产色| 青草久久国产| 欧美成人性av电影在线观看| xxx96com| 久久人人精品亚洲av| 禁无遮挡网站| 两性午夜刺激爽爽歪歪视频在线观看| 久久久久久久久久黄片| 性欧美人与动物交配| 国产一区二区三区视频了| 免费看美女性在线毛片视频| 亚洲天堂国产精品一区在线| 最好的美女福利视频网| 男插女下体视频免费在线播放| 国产亚洲精品一区二区www| 国产精品免费一区二区三区在线| 色视频www国产| 成人特级黄色片久久久久久久| 观看美女的网站| 国产成人a区在线观看| 欧美在线黄色| 国产精品美女特级片免费视频播放器| 欧美日韩精品网址| 噜噜噜噜噜久久久久久91| 色尼玛亚洲综合影院| 免费看a级黄色片| 一本一本综合久久| 老熟妇乱子伦视频在线观看| 欧美性猛交黑人性爽| 亚洲国产精品久久男人天堂| av天堂在线播放| 男插女下体视频免费在线播放| 日韩国内少妇激情av| 国产一区二区激情短视频| 国产高清videossex| 日韩欧美精品v在线| 欧美乱妇无乱码| 亚洲色图av天堂| or卡值多少钱| 高潮久久久久久久久久久不卡| 在线观看一区二区三区| 免费在线观看成人毛片| 国内精品美女久久久久久| 我要搜黄色片| 丁香六月欧美| 草草在线视频免费看| 亚洲一区高清亚洲精品| 老熟妇仑乱视频hdxx| 俺也久久电影网| 欧美不卡视频在线免费观看| 欧美日韩中文字幕国产精品一区二区三区| 在线播放国产精品三级| 亚洲国产精品999在线| 亚洲人与动物交配视频| 免费av不卡在线播放| 亚洲av第一区精品v没综合| 成人精品一区二区免费| 深夜精品福利| 在线播放国产精品三级| 亚洲成人中文字幕在线播放| 一级作爱视频免费观看| 在线天堂最新版资源| 母亲3免费完整高清在线观看| 无限看片的www在线观看| 变态另类丝袜制服| 国产高清三级在线| 黄色女人牲交| 亚洲av不卡在线观看| 久久人人精品亚洲av| 美女 人体艺术 gogo| 国产免费男女视频| 亚洲狠狠婷婷综合久久图片| 成人欧美大片| 五月玫瑰六月丁香| 国产综合懂色| 国产免费av片在线观看野外av| 亚洲欧美精品综合久久99| 午夜影院日韩av| 别揉我奶头~嗯~啊~动态视频| 亚洲中文字幕日韩| 久久天躁狠狠躁夜夜2o2o| 亚洲国产精品合色在线| 一个人免费在线观看电影| xxx96com| 3wmmmm亚洲av在线观看| 国产精品亚洲av一区麻豆| 婷婷精品国产亚洲av在线| 操出白浆在线播放| 人妻夜夜爽99麻豆av| 欧美成狂野欧美在线观看| av福利片在线观看| 一个人观看的视频www高清免费观看| 久久精品国产亚洲av涩爱 | 免费av不卡在线播放| 欧美日韩乱码在线| 欧美日韩国产亚洲二区| 最近视频中文字幕2019在线8| 少妇的逼水好多| 久久久国产精品麻豆| 天堂av国产一区二区熟女人妻| 哪里可以看免费的av片| 天堂网av新在线| 天堂动漫精品| 久久久精品大字幕| 天堂动漫精品| 亚洲欧美日韩高清在线视频| 日本精品一区二区三区蜜桃| 最新美女视频免费是黄的| 久久中文看片网| 尤物成人国产欧美一区二区三区| 国产蜜桃级精品一区二区三区| 99久久综合精品五月天人人| 一级a爱片免费观看的视频| 免费看日本二区| 精华霜和精华液先用哪个| 婷婷丁香在线五月| 2021天堂中文幕一二区在线观| 色视频www国产| 亚洲欧美日韩无卡精品| 国产精品久久久久久久久免 | 岛国在线观看网站| 亚洲aⅴ乱码一区二区在线播放| 久久精品国产亚洲av涩爱 | 精品国产超薄肉色丝袜足j| 免费观看的影片在线观看| 日本黄色视频三级网站网址| 国产精品久久视频播放| 国语自产精品视频在线第100页| 亚洲精华国产精华精| 在线观看免费视频日本深夜| 欧美成人一区二区免费高清观看| 国产老妇女一区| 美女cb高潮喷水在线观看| 999久久久精品免费观看国产| 日韩亚洲欧美综合| 国产午夜福利久久久久久| 99在线视频只有这里精品首页| 在线观看av片永久免费下载| 精品无人区乱码1区二区| 亚洲成人久久性| 午夜激情福利司机影院| 亚洲美女黄片视频| 老司机福利观看| 国产免费av片在线观看野外av| 九色国产91popny在线| 精华霜和精华液先用哪个| 欧洲精品卡2卡3卡4卡5卡区| 午夜免费观看网址| 高潮久久久久久久久久久不卡| 女生性感内裤真人,穿戴方法视频| 国产欧美日韩精品一区二区| 最近视频中文字幕2019在线8| 熟妇人妻久久中文字幕3abv| 免费人成视频x8x8入口观看|