• <tr id="yyy80"></tr>
  • <sup id="yyy80"></sup>
  • <tfoot id="yyy80"><noscript id="yyy80"></noscript></tfoot>
  • 99热精品在线国产_美女午夜性视频免费_国产精品国产高清国产av_av欧美777_自拍偷自拍亚洲精品老妇_亚洲熟女精品中文字幕_www日本黄色视频网_国产精品野战在线观看 ?

    Clinical Study on Point Application Using Chinese Herbal Medicine for Pediatric Chronic Cough

    2014-06-19 17:42:12

    Department of Pediatrics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

    CLINICAL STUDY

    Clinical Study on Point Application Using Chinese Herbal Medicine for Pediatric Chronic Cough

    Shen Jian, Zong Nan-wei, Zhu Sheng-guo, Zhao Jun, Gu Ming-da, Zhou Jun-hui

    Department of Pediatrics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

    Author: Shen Jian, M.D., attending physician

    Objective: To observe the clinical effect of point application using Chinese herbal medicine for chronic cough in children.

    Methods: A total of 200 children with chronic cough were randomly allocated into an observation group and a control group, 100 cases in each group. Conventional Western medication was used for cases in the control group, whereas conventional Western medication plus point application using Chinese herbal medicine were used for cases in the observation group. Changes of indexes including eosinophils (EOS), peak expiratory flow (PEF) and forced expiratory volume in one second (FEV1) were observed before and after treatment. In addition, the clinical effects were compared between the two groups.

    Results: After treatment,coughs in children were alleviated in both groups; however, it took a shorter period of time for cough alleviation in the observation group than that in the control group (P<0.01). On the 28th day of treatment, the EOS, PEF and FEV1were improved in both groups (P<0.01), and the improvements were more significant in the observation group (P<0.05). Additionally, the frequencies of cough variant asthma attacks were decreased in both groups, but a better effect in the observation group than the control group.

    Conclusion: Complementary point application using Chinese herbal medicine could substantially improve the clinical effect, alleviate coughs and benefit lung functions.

    Cough; Asthma; Acupoint Therapy; Point Application Therapy; Children

    Chronic cough is one of the common respiratory system problems in children and can be a symptom of many conditions. It is often caused by multiple factors and can last a long period of time. As an important bodily defense mechanism, cough helps to clear secretions and foreign bodies of the airway and thus stop respiratory infection from spreading. However incorrect or delayed treatment of cough can affect the children’s normal life, growth and development. On top of conventional Western medication, we’ve combined point application using Chinese herbal medicine and observed the clinical effect. The results are now summarized as follows.

    1 Clinical Materials

    1.1 Diagnostic criteria

    The diagnosis can be made according to the 2008Diagnosis and Treatment Guidelines for Pediatric Chronic Cough(Trial)[1]: cough lastingover 4 weeks; excluding specific cough due to pulmonary tuberculosis and normal findings in chest X-ray examination.

    Cough due to phlegm-heat in Chinese medicine can be diagnosed according to theIntegrated Traditional Chinese and Western Medicine Expert Consensus on Diagnosis and Treatment of Pediatric Cough[2]: cough with sticky phlegm, sweating, and a red tongue with thin yellow coating or slightly greasy coating.

    1.2 Inclusion criteria

    Those who met the aforementioned diagnostic criteria; aged between 5 and 14 years old; having an allergic constitution or allergic history; and parents of the children were willing to participate in this trial and sign the informed consent.

    1.3 Exclusion criteria

    Those with complications of severe malnutrition, rickets, primary conditions of heart, liver, kidney and hematopoietic systems or consumptive diseases;having primary immunodeficiency disease or pulmonary hypoplasia; psychogenic cough; those with a long-term use of glucocorticoids, antibiotics and immunosuppressive agents; allergic to above formula ingredients; those who failed to cooperate; and those who tend to be lost to follow-up.

    1.4 Rejection and termination criteria

    Those who were included in violation of the inclusion criteria; those who failed to follow the treatment protocol; drop-out or loss of follow-up;those with incomplete material affecting efficacy evaluation; those with deteriorated conditions or severe complications and were terminated by researchers; those having severe adverse reactions;and those who were unwilling or unlikely to continue with the clinical observation and therefore quitted or terminated from the trial.

    1.5 Statistical method

    The Microsoft Excel, SPSS 17.0 version statistical software and superiority test method were used. The measurement data were expressed asPairedt-test was used for intra-group comparison in normal distribution, groupt-test for inter-group comparison, rank sum test for intra-group comparison in abnormal distribution and Chi-square test for numeration data.

    1.6 General data

    This study adopted randomized controlled clinical trial design. A total of 200 cases from the Outpatient Department of Pediatrics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between May 2012 and October 2012 were randomly allocated into an observation group and a control group, 100 cases in each group. Of 100 cases in the observation group, 37 had upper airway cough syndrome, 50 had cough-variant asthma, 11 had infection-related cough and 2 had other conditions. Of 100 cases in the control group, 36 had upper airway cough syndrome, 51 had cough-variant asthma, 11 had infection-related cough and 2 had other conditions. There were no rejection or drop-out cases in the two groups. The one-year follow-up on cough-variant asthma cases in the two groups had 1 case in the control group dropped out.

    Parents of all children signed the informed consent. There were no statistically significant differences in age, gender, duration and disease nature between two groups (P>0.05), indicating that the two groups were comparable (Table 1).

    Table 1. Between-group comparison on general materials

    2 Treatment Methods

    2.1 Observation group

    2.1.1 Conventional Western medication

    Anti-inflammatory, anti-anaphylaxis and spasmolytic medications were employed, along with sensitivity antibiotics for infection.

    2.1.2 Point application therapy

    Ingredients of Chinese herbal formula: Coughrelieving formula [powder ofBing Pian(Borneolum Syntheticum),Wu Wei Zi(Fructus Schisandrae Chinensis) andBai Zhi(Radix Angelicae Dahuricae) by the ratio of 1:6:6] and phlegm-resolving formula [powder ofDing Xiang(Flos Caryophylli),Rou Gui(Cortex Cinnamomi),Wu Bei Zi(Galla Chinensis) andWu Wei Zi(Fructus Schisandrae Chinensis) by the ratio of 1:4:4:4]. The formula was provided by Chinese Herbal Preparation Room, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.

    Points: Tiantu (CV 22) and Dazhui (GV 14).

    Method: Apply 0.5 g of cough-relieving formula to Tiantu (CV 22) and 0.5 g of phlegm-resolving formula to Dazhui (GV 14), cover the powder with dressings. The point application was done once a day, 6 h for each time and 3 d for a small course of treatment. There was a 4-day interval after 3 d. Four weeks made up a course of treatment.

    2.2 Control group

    Children in the control group were treated with the same conventional Western medication as the observation group.

    3 Therapeutic Efficacy Observation

    3.1 Observation indexes

    3.1.1 Signs and symptoms

    Using the self-made traditional Chinese medicine symptom scale, clinical signs and symptoms such as cough and phlegm expectoration were observed and recorded before and after treatment.

    3.1.2 Eosinophils (EOS), peak expiratory flow (PEF) and forced expiratory volume in one second (FEV1)

    EOS, PEF and FEV1were observed before and after treatment. EOS value was obtained by routine blood test and PEF and FEV1by PiKO-1.

    3.1.3 The childhood asthma control test (CACT) scale

    The CACT scores were observed before and after treatment. Since asthma patients in this group were aged between 4 and 11 and therefore suitable for understanding how asthma was controlled and managed. The score ≤19 indicates poorly controlled asthma; the score ≥20 indicates that asthma is under control.

    3.2 Criteria for therapeutic efficacy

    This criterion is made according to the 2008Diagnosis and Treatment Guidelines for ChronicPediatric Cough(Trial)[1]andGuiding Principles for Clinical Study of New Chinese Medicines[3]. The Nimodipine method was used to calculate decrease rate of symptom scores.

    The decrease rate of symptom score = (Before treatment score — After treatment score) ÷ Before treatment score × 100%.

    Clinical control: Almost absence of signs and symptoms, decrease rate of symptom score is ≥95%.

    Marked effect: Significant improvement of signs and symptoms, decrease rate of symptom score is between 70% and 94%.

    Improvement: Alleviated but unstable recurrent signs and symptoms, decrease rate of symptom score is between 30% and 69%.

    Failure: The decrease rate of symptom score is less than 30%.

    3.3 Results

    3.3.1 Between-group comparison on clinical effects

    After 28 d of treatment, there were between-group significant differences in recovery rate and total effective rate (P<0.05) and a better effect in the observation group than that in the control group (Table 2).

    Table 2. Between-group comparison on clinical effects (case)

    3.3.2 Between-group comparison on lung functions

    After treatment, the FEV1and PEF (% predicted value) in both groups were significantly improved (P<0.01), along with a better effect in the observation group than that in the control group (P<0.05), (Table 3).

    3.3.3 Between-group comparison on cough disappearance time

    The cough disappearance time in the observation group was (5.2±2.8) d, versus (8.5±1.2) d in the control group, showing a statistically significant difference (P<0.01).

    3.3.4 Between-group comparison on annual asthma attacks

    The 1-year follow-up on children with coughvariant asthma in two groups (1 case dropped out in the control group) has shown that the annual asthma attacks, EOS and CACT scores in both groups were significantly decreased (P<0.01) after treatment, along with a better result in the observation group than that in the control group (P<0.05), (Table 4).

    Table 3. Between-group comparison on lung function indexes before and after treatment (% predicted value)

    Table 3. Between-group comparison on lung function indexes before and after treatment (% predicted value)

    Note: Intra-group comparison between before and after treatment, 1) P<0.01; inter-group comparison after treatment, 2) P<0.05

    3.3.5 Adverse reactions

    Due to tender skin of children and long-time sticking, 3 patients in the observation group experienced local skin redness or mild itch and 1 patient had mild skin ulceration, which were alleviated 2 d later after local cleaning and application of Iodophors or Fluocinolone Acetonide.

    Table 4. Between-group comparison on frequency of annual asthma attacks, EOS and CACT changes

    Table 4. Between-group comparison on frequency of annual asthma attacks, EOS and CACT changes

    Note: Intra-group comparison between before and after treatment, 1) P<0.01; inter-group comparison after treatment, 2) P<0.01, 3) P<0.05

    ?

    4 Discussion

    Chronic cough is one of the most common respiratory tract diseases in childhood. Yang SL et al described pulse conditions and causative factors of cough[4]. Cough is a common chief complaint of numerous diseases. Chronic cough in children can be caused by multiple factors. In addition to chronic rhinitis, chronic bronchitis, cough following upper respiratory tract infection, cough-variant asthma and gastroesophageal reflux (GER), other conditions may include atopic cough, episodic respiratory symptoms without asthma and eosinophilic bronchitis.

    Chronic airway inflammation can lead to hyperreactivity; the inflammation persists even during remission. Left untreated, many children with recurrent or persistent may eventually develop adult asthma. EOS infiltration in airway inflammation is pathophysiologically distinctive from other inflammations and known as an indicative marker of asthma inflammation[5]. FEV1is considered the best index for assessment of airway obstruction severity. PEF is a key index for airway resistance. Considering different PEF values from different peak expiratory flow meters, we’ve adopted % predicted value (measured PEF value/previous self-measured optimal PEF value). As a simple way to evaluate the lung function, the CACT is easy to operate and highly reliable.

    In traditional Chinese medicine, recurrent respiratory tract inflection occurs as a result of fierce struggle between healthy qi and pathogenic factors. Point application using Chinese herbal medicine has been extensively used in the treatment of respiratory system diseases[6-10]. Tiantu (CV 22) is located in the depression at the center of suprasternal notch;stimulating this point can relieve qi stagnation, alleviate cough and resolve phlegm. Dazhui (GV 14) is a crossing point between the Governor Vessel and three yang meridians; stimulating this point can resolve phlegm and stasis, regulate meridian qi, activate yang qi of the lung and spleen and strengthen lung and Wei-defensive qi[11]. In addition, pungent, fragrant and phlegm-resolving herbs were combined to further consolidate the effect of warming yang, activating qi and boosting the immune system. The study has suggested that conventional Western medication plus point application using Chinese herbal medicine works well for chronic cough in children. It can significantly reduce asthma episodes, improve EOS, FEV1, PEF and CACT scores and benefit the immune function. This can further promote healthy maturity of immune organs, reduce respiratory tract infection and airway hyper-reactivity and thus prevent and treat asthma. This easy-tooperate, safe and low-cost method causes few or no side effects and deserves more extensive use in the future.

    Conflict of Interest

    The authors declared that there was no conflict of interest in this article.

    Acknowledgments

    This work was supported by Xu’s Pediatric Clinical Experience Inheritance Base (No. ZYSNXD-CC-HPGCJD-005); Emerging Frontier Technology Joint Research Program of Shanghai Municipal Hospitals (No. SHDC12012410); Domestic Visiting Scholar Program for Young Teachers at Shanghai Colleges and Universities; Tang Wei-yong Work Room of Shanghai Three-year Action Plan of Traditional Chinese Medicine (No. ZYSNXD-CC-MZY001); Cheng Jia-zheng Work Room of Three-year Action Plan of Traditional Chinese Medicine (No. ZYSNXD-CC-MZY002); and the Third Group Construction Project of Clinical Advantages Specialized Subject of Traditional Chinese Medicine in Shanghai (No. ZYSNXD-YL-YSZK006).

    Statement of Informed Consent

    Informed consent was obtained from all individual participants’ parents included in this study.

    [1] Task force on respiratory disease, Chinese Society of Pediatrics, Editorial Committee of Chinese Journal of Pediatrics. Diagnosis and treatment guidelines for chronic pediatric cough (trial). Zhonghua Erke Zazhi, 2008, 46(2): 104-107.

    [2] Lu Q, Wang XF, Chen HZ, Hong JG, Hu YJ, Lu YX, Ma R, Shang YX, Wang LY, Wang SM, Xu RQ. Integrated traditional Chinese and Western medicine expert consensus on diagnosis and treatment of pediatric cough. Zhongguo Shiyong Erke Zazhi, 2010, 25(6): 439-443.

    [3] Ministry of Health of the People’s Republic of China. Guiding Principles for Clinical Study of New Chinese Medicines. Beijing: China Medico-Pharmaceutical Science & Technology Publishing House, 2002: 57.

    [4] Yang SL, Ma FL, Nie J, Qin Q, Qiao L, Zhang JY, Zhang M. Analysis on diagnosis and treatment rules of cough in theYi Xue Zheng Zhi Ze Yao. Henan Zhongyi, 2013, 33(6): 872-873.

    [5] Busse WW, Calhoun WF, Sedgwick JD. Mechanism of airway inflammation in asthma. Am Rev Respir Dis, 1993, 147(6 Pt 2): 20-24.

    [6] Li LP. Clinical observation on acupoint application in preventing and treating bronchial asthma. Shanghai Zhenjiu Zazhi, 2013, 32(2): 96-97.

    [7] Xu SW, Zhang BM, Zhou JM, Hu ZH, Pan CA, Wang Y, Shou Y, Yang Y, Liu MM. Clinical observation on acupuncture plus acupoint sticking for bronchial asthma in remissive state. J Acupunct Tuina Sci, 2013, 11(5): 326-330.

    [8] Jiang WQ, Lou WS, Zhang YJ, Zhu FJ, Chen YB. Therapeutic observation on acupoint sticking therapy plus pricking Sifeng (EX-UE 10) for recurrent respiratory infection in children. Shanghai Zhenjiu Zazhi, 2013, 32(9): 740-741.

    [9] Tong Q, Liang YP, Zheng ZT. Influence of acupoint application therapy on biochemical indexes of asthma patients in remission period. J Acupunct Tuina Sci, 2010, 8(3): 184-188.

    [10] Sun J, Wang Y. Concurrent supplementation of antipathogenic qi and removal of pathogenic factors for prevention of pediatric recurrent respiratory tract infection. Zhongguo Zhongyiyao Xiandai Yuancheng Jiaoyu, 2013, 11(4): 97-98.

    [11] Huang QF, Liu LG, Gu J, Wu HG. Analysis of the characteristics of moxibustion treatment for cough. Shanghai Zhenjiu Zazhi, 2010, 29(8): 483-485.

    Translator:Han Chou-ping

    Zhu Shengguo, chief physician.

    E-mail: shuguangerke@126.com

    R246.4

    : A

    Date:February 25, 2014

    亚洲精华国产精华液的使用体验 | 亚洲精品影视一区二区三区av| 国产精品一区www在线观看| 性欧美人与动物交配| a级一级毛片免费在线观看| 国产精品1区2区在线观看.| 午夜福利在线在线| 自拍偷自拍亚洲精品老妇| 深夜精品福利| 国产精品嫩草影院av在线观看| 亚洲欧美精品综合久久99| 国产亚洲精品综合一区在线观看| 久久欧美精品欧美久久欧美| 国产成人福利小说| 国产成人aa在线观看| 亚洲av电影不卡..在线观看| 国产精品野战在线观看| 成人毛片a级毛片在线播放| 国产精品,欧美在线| 国产黄色小视频在线观看| 久久人人爽人人片av| 免费人成在线观看视频色| 全区人妻精品视频| 国产成年人精品一区二区| 久久韩国三级中文字幕| 免费观看的影片在线观看| 久久久久国内视频| 在线播放国产精品三级| 国产熟女欧美一区二区| 国产一区亚洲一区在线观看| 高清毛片免费观看视频网站| 亚洲人成网站高清观看| 夜夜看夜夜爽夜夜摸| 久久婷婷人人爽人人干人人爱| 日日干狠狠操夜夜爽| 美女高潮的动态| 日韩欧美在线乱码| 午夜福利18| 最近视频中文字幕2019在线8| 国产成人aa在线观看| 国产欧美日韩精品一区二区| 男人舔奶头视频| 亚洲内射少妇av| 日韩亚洲欧美综合| 啦啦啦观看免费观看视频高清| 插逼视频在线观看| 长腿黑丝高跟| 成人av在线播放网站| 精品久久久噜噜| 欧美三级亚洲精品| 女生性感内裤真人,穿戴方法视频| 在现免费观看毛片| 精品国内亚洲2022精品成人| 日韩av不卡免费在线播放| 变态另类丝袜制服| 亚洲成人久久爱视频| 成人一区二区视频在线观看| 三级国产精品欧美在线观看| 久久久精品94久久精品| 久久精品国产亚洲网站| 国产探花极品一区二区| 精华霜和精华液先用哪个| 在线观看美女被高潮喷水网站| 国产日本99.免费观看| 亚洲国产日韩欧美精品在线观看| 国产精品久久久久久亚洲av鲁大| 成人午夜高清在线视频| 久久久久精品国产欧美久久久| 欧美+日韩+精品| 亚洲欧美成人精品一区二区| 久久午夜亚洲精品久久| av卡一久久| 最近2019中文字幕mv第一页| 少妇的逼水好多| 国产乱人视频| 91久久精品国产一区二区三区| 最近的中文字幕免费完整| 麻豆一二三区av精品| 波多野结衣高清无吗| 亚洲精品粉嫩美女一区| 少妇熟女欧美另类| 男女那种视频在线观看| 欧美潮喷喷水| 日日摸夜夜添夜夜添av毛片| 亚洲av五月六月丁香网| 久久欧美精品欧美久久欧美| 长腿黑丝高跟| 免费观看的影片在线观看| 亚洲国产精品久久男人天堂| 日日摸夜夜添夜夜添av毛片| 黄色日韩在线| 久久久午夜欧美精品| 久久国产乱子免费精品| 狠狠狠狠99中文字幕| 人妻久久中文字幕网| 欧美不卡视频在线免费观看| 日韩三级伦理在线观看| 午夜激情福利司机影院| 欧美日韩国产亚洲二区| 欧美日韩精品成人综合77777| 99国产精品一区二区蜜桃av| 国产精品久久电影中文字幕| 悠悠久久av| 淫秽高清视频在线观看| 成人亚洲精品av一区二区| 网址你懂的国产日韩在线| 国产蜜桃级精品一区二区三区| 国模一区二区三区四区视频| 看黄色毛片网站| av在线观看视频网站免费| 亚洲性夜色夜夜综合| 性欧美人与动物交配| 欧美不卡视频在线免费观看| 床上黄色一级片| 可以在线观看的亚洲视频| 少妇的逼水好多| 国产男靠女视频免费网站| 欧美性感艳星| 久久久a久久爽久久v久久| 亚洲电影在线观看av| 国产av不卡久久| 久99久视频精品免费| 亚洲欧美成人精品一区二区| 少妇被粗大猛烈的视频| 最后的刺客免费高清国语| 免费观看精品视频网站| av在线观看视频网站免费| 精品免费久久久久久久清纯| 又黄又爽又刺激的免费视频.| 日本-黄色视频高清免费观看| 天堂动漫精品| 免费看av在线观看网站| 亚洲av二区三区四区| 日韩三级伦理在线观看| 一级av片app| 日韩精品中文字幕看吧| 婷婷六月久久综合丁香| 国产成人影院久久av| 国内精品久久久久精免费| 神马国产精品三级电影在线观看| 少妇猛男粗大的猛烈进出视频 | 亚洲不卡免费看| 在线天堂最新版资源| 国产国拍精品亚洲av在线观看| 午夜激情欧美在线| 国语自产精品视频在线第100页| av免费在线看不卡| 美女高潮的动态| 人人妻人人澡人人爽人人夜夜 | 如何舔出高潮| 99久久久亚洲精品蜜臀av| or卡值多少钱| 又爽又黄a免费视频| 91久久精品电影网| 欧美zozozo另类| 乱码一卡2卡4卡精品| 久久热精品热| 性插视频无遮挡在线免费观看| 国产在线精品亚洲第一网站| 一级a爱片免费观看的视频| 久久午夜福利片| 啦啦啦观看免费观看视频高清| 最好的美女福利视频网| 性插视频无遮挡在线免费观看| 啦啦啦观看免费观看视频高清| 村上凉子中文字幕在线| videossex国产| 欧美潮喷喷水| 亚洲精品成人久久久久久| 在线观看午夜福利视频| 尾随美女入室| 国产私拍福利视频在线观看| 国产69精品久久久久777片| 老熟妇乱子伦视频在线观看| 天堂动漫精品| 蜜桃久久精品国产亚洲av| 寂寞人妻少妇视频99o| 噜噜噜噜噜久久久久久91| 午夜精品国产一区二区电影 | 亚洲精品一区av在线观看| 91久久精品国产一区二区成人| 国产色婷婷99| 日本与韩国留学比较| 亚洲精品影视一区二区三区av| 联通29元200g的流量卡| 18禁黄网站禁片免费观看直播| 18禁裸乳无遮挡免费网站照片| a级一级毛片免费在线观看| 日韩中字成人| 日韩欧美精品免费久久| 熟妇人妻久久中文字幕3abv| 国产国拍精品亚洲av在线观看| 久久草成人影院| 亚洲欧美精品自产自拍| 久久6这里有精品| 成人美女网站在线观看视频| 一a级毛片在线观看| 午夜精品在线福利| 又黄又爽又免费观看的视频| a级毛片免费高清观看在线播放| 亚洲av不卡在线观看| 国产女主播在线喷水免费视频网站 | 性插视频无遮挡在线免费观看| 国产精品电影一区二区三区| 久久久成人免费电影| 能在线免费观看的黄片| 国产成人freesex在线 | 1024手机看黄色片| 久久草成人影院| 国内精品一区二区在线观看| a级毛片免费高清观看在线播放| 内地一区二区视频在线| 精品人妻偷拍中文字幕| 丝袜美腿在线中文| 亚洲欧美成人精品一区二区| 国产国拍精品亚洲av在线观看| 女的被弄到高潮叫床怎么办| 亚洲精品亚洲一区二区| 禁无遮挡网站| 国产在线精品亚洲第一网站| 一个人看的www免费观看视频| 一a级毛片在线观看| 一区二区三区四区激情视频 | 真实男女啪啪啪动态图| 午夜福利高清视频| 国产精品女同一区二区软件| 国产单亲对白刺激| 日韩在线高清观看一区二区三区| 午夜福利在线在线| 99国产精品一区二区蜜桃av| 成人二区视频| 欧美日韩国产亚洲二区| 亚洲欧美成人综合另类久久久 | 婷婷色综合大香蕉| or卡值多少钱| 欧美色欧美亚洲另类二区| 亚洲中文日韩欧美视频| 夜夜看夜夜爽夜夜摸| 在线免费观看的www视频| 最近的中文字幕免费完整| 国产午夜精品论理片| 少妇丰满av| 一夜夜www| 99热这里只有精品一区| 久久鲁丝午夜福利片| 18禁黄网站禁片免费观看直播| 欧美在线一区亚洲| 亚洲不卡免费看| 国产老妇女一区| 美女黄网站色视频| 男人的好看免费观看在线视频| 国产麻豆成人av免费视频| 看黄色毛片网站| 精品人妻视频免费看| 91久久精品国产一区二区成人| 亚洲不卡免费看| 女同久久另类99精品国产91| 最好的美女福利视频网| 少妇裸体淫交视频免费看高清| 成人鲁丝片一二三区免费| 91狼人影院| 日日啪夜夜撸| a级毛片a级免费在线| 欧美丝袜亚洲另类| 赤兔流量卡办理| 亚洲真实伦在线观看| 国产精品女同一区二区软件| 麻豆av噜噜一区二区三区| 精品国内亚洲2022精品成人| 女同久久另类99精品国产91| 国产精品一及| 最近在线观看免费完整版| 国产在线男女| 亚洲精品亚洲一区二区| 久久综合国产亚洲精品| 色av中文字幕| 亚洲av二区三区四区| 在线免费观看的www视频| 亚洲国产色片| 精品久久久久久久人妻蜜臀av| 亚洲av中文av极速乱| 深爱激情五月婷婷| 女的被弄到高潮叫床怎么办| h日本视频在线播放| 久久中文看片网| 日韩亚洲欧美综合| 看片在线看免费视频| av在线观看视频网站免费| av在线播放精品| 欧洲精品卡2卡3卡4卡5卡区| 女同久久另类99精品国产91| 十八禁网站免费在线| 少妇熟女欧美另类| 白带黄色成豆腐渣| 亚洲熟妇熟女久久| 成人二区视频| 免费无遮挡裸体视频| 人人妻人人看人人澡| 村上凉子中文字幕在线| 热99re8久久精品国产| 精品一区二区三区人妻视频| 久久久久九九精品影院| 99视频精品全部免费 在线| 最近中文字幕高清免费大全6| 亚洲av中文字字幕乱码综合| 哪里可以看免费的av片| 精品国内亚洲2022精品成人| 哪里可以看免费的av片| 99热精品在线国产| 九色成人免费人妻av| 日韩欧美国产在线观看| 国产精品一及| 最近最新中文字幕大全电影3| 日韩欧美精品v在线| 中国美女看黄片| 联通29元200g的流量卡| 在线观看av片永久免费下载| 国产精华一区二区三区| 亚洲国产高清在线一区二区三| 久久韩国三级中文字幕| 网址你懂的国产日韩在线| 69人妻影院| 色5月婷婷丁香| 丰满乱子伦码专区| 久久久久久久久中文| 国产黄a三级三级三级人| 国产 一区 欧美 日韩| 一区福利在线观看| 亚洲国产精品久久男人天堂| 九九久久精品国产亚洲av麻豆| 成熟少妇高潮喷水视频| 在线观看一区二区三区| 亚洲美女搞黄在线观看 | 国产v大片淫在线免费观看| 此物有八面人人有两片| 非洲黑人性xxxx精品又粗又长| 人妻夜夜爽99麻豆av| 最近手机中文字幕大全| 国产极品精品免费视频能看的| 久久午夜福利片| 国语自产精品视频在线第100页| 亚洲av熟女| 国产精品99久久久久久久久| 少妇裸体淫交视频免费看高清| 亚洲国产日韩欧美精品在线观看| 欧美性感艳星| 日韩国内少妇激情av| 少妇裸体淫交视频免费看高清| 亚洲国产日韩欧美精品在线观看| 免费观看人在逋| 日韩在线高清观看一区二区三区| www.色视频.com| 亚洲国产色片| 亚洲国产精品合色在线| 亚洲av美国av| 国产成人aa在线观看| 内射极品少妇av片p| 亚洲精品日韩av片在线观看| 亚洲欧美中文字幕日韩二区| 色综合色国产| 亚洲一级一片aⅴ在线观看| 精品人妻熟女av久视频| 日韩在线高清观看一区二区三区| 色噜噜av男人的天堂激情| 国内精品宾馆在线| 精品久久久久久久人妻蜜臀av| 亚洲精品在线观看二区| 免费大片18禁| 欧美成人精品欧美一级黄| 国产精品亚洲美女久久久| 蜜臀久久99精品久久宅男| 国产精品爽爽va在线观看网站| 热99re8久久精品国产| 欧美高清成人免费视频www| 久久亚洲精品不卡| 美女 人体艺术 gogo| 少妇高潮的动态图| 男人舔女人下体高潮全视频| 久久久色成人| 国产精品亚洲美女久久久| av在线天堂中文字幕| 国产精品人妻久久久久久| 97在线视频观看| 小蜜桃在线观看免费完整版高清| 18禁在线播放成人免费| 久久久久国产网址| 男女视频在线观看网站免费| 国产熟女欧美一区二区| 亚洲国产色片| 日本五十路高清| 色视频www国产| 国产精品久久久久久亚洲av鲁大| 日韩高清综合在线| 免费av观看视频| 国产一区二区在线观看日韩| 免费看日本二区| 婷婷色综合大香蕉| 在线播放国产精品三级| 精品午夜福利在线看| 亚洲三级黄色毛片| or卡值多少钱| 亚洲欧美日韩东京热| 两个人视频免费观看高清| 白带黄色成豆腐渣| 亚洲欧美清纯卡通| 国产免费一级a男人的天堂| 欧美色视频一区免费| 精品熟女少妇av免费看| 在线免费十八禁| 午夜福利高清视频| 欧美丝袜亚洲另类| 久久精品国产自在天天线| 亚洲不卡免费看| 国产精品一及| 国产伦精品一区二区三区四那| 噜噜噜噜噜久久久久久91| 国产精品亚洲美女久久久| 一区二区三区四区激情视频 | 国产午夜精品久久久久久一区二区三区 | 真实男女啪啪啪动态图| 国产成人福利小说| 亚洲性久久影院| 岛国在线免费视频观看| 亚洲人成网站在线播放欧美日韩| 在线免费十八禁| 久久久午夜欧美精品| 成人二区视频| 丰满的人妻完整版| 亚洲欧美日韩高清在线视频| a级毛片免费高清观看在线播放| 日韩成人伦理影院| 少妇猛男粗大的猛烈进出视频 | 久久久久久久久久黄片| 99九九线精品视频在线观看视频| 国产探花极品一区二区| 欧美成人一区二区免费高清观看| 亚洲欧美精品自产自拍| 久久精品国产亚洲网站| 男人舔女人下体高潮全视频| 亚洲人成网站高清观看| 淫秽高清视频在线观看| 欧美激情久久久久久爽电影| 在线观看午夜福利视频| 22中文网久久字幕| 91精品国产九色| www.色视频.com| 日韩大尺度精品在线看网址| or卡值多少钱| 免费无遮挡裸体视频| 午夜福利视频1000在线观看| 22中文网久久字幕| 中出人妻视频一区二区| 免费av毛片视频| 免费观看精品视频网站| 国产一区二区在线av高清观看| 99热精品在线国产| 亚洲综合色惰| 欧美成人精品欧美一级黄| 97人妻精品一区二区三区麻豆| 日本成人三级电影网站| 女人十人毛片免费观看3o分钟| 国产老妇女一区| 简卡轻食公司| 搡老岳熟女国产| 又爽又黄a免费视频| 久久精品影院6| 91狼人影院| 夜夜爽天天搞| 国产女主播在线喷水免费视频网站 | 三级经典国产精品| 好男人在线观看高清免费视频| 人人妻,人人澡人人爽秒播| 午夜福利成人在线免费观看| 美女黄网站色视频| 国产亚洲精品综合一区在线观看| 免费搜索国产男女视频| 精品一区二区三区视频在线观看免费| 香蕉av资源在线| 精品一区二区三区视频在线| 欧美不卡视频在线免费观看| 欧美日韩乱码在线| 亚洲人成网站在线观看播放| 亚洲熟妇熟女久久| 男女那种视频在线观看| av免费在线看不卡| 在线播放国产精品三级| 久久精品夜夜夜夜夜久久蜜豆| 成人鲁丝片一二三区免费| 婷婷精品国产亚洲av在线| 三级毛片av免费| 大型黄色视频在线免费观看| 国产欧美日韩一区二区精品| 久久精品91蜜桃| 日韩高清综合在线| 亚洲成人av在线免费| 天天躁日日操中文字幕| 波野结衣二区三区在线| 精品久久久久久久末码| 网址你懂的国产日韩在线| 女人十人毛片免费观看3o分钟| 免费观看在线日韩| 亚洲一区高清亚洲精品| 久久久久久伊人网av| 亚洲人成网站在线观看播放| av卡一久久| 22中文网久久字幕| 国产精品久久电影中文字幕| 床上黄色一级片| 国产精品乱码一区二三区的特点| 美女cb高潮喷水在线观看| 亚洲真实伦在线观看| 亚洲第一电影网av| 淫秽高清视频在线观看| 在线观看66精品国产| 久久精品夜色国产| 菩萨蛮人人尽说江南好唐韦庄 | 国产亚洲精品久久久com| 三级国产精品欧美在线观看| 美女cb高潮喷水在线观看| 中文亚洲av片在线观看爽| 18禁在线无遮挡免费观看视频 | 热99re8久久精品国产| 国内揄拍国产精品人妻在线| 免费一级毛片在线播放高清视频| 色播亚洲综合网| 欧美一区二区精品小视频在线| 女的被弄到高潮叫床怎么办| 长腿黑丝高跟| 日韩精品中文字幕看吧| 国产精品一区www在线观看| 一a级毛片在线观看| 欧美潮喷喷水| 少妇猛男粗大的猛烈进出视频 | 丰满乱子伦码专区| 亚洲精品一卡2卡三卡4卡5卡| 最近2019中文字幕mv第一页| 男女做爰动态图高潮gif福利片| 精品久久久久久久人妻蜜臀av| 国产成人a∨麻豆精品| 国产乱人视频| 久久久久久久久久久丰满| 亚洲精品国产成人久久av| 精品福利观看| 国产中年淑女户外野战色| 热99在线观看视频| 午夜免费男女啪啪视频观看 | 国产高清视频在线播放一区| 99热这里只有精品一区| 久久久精品94久久精品| 在线a可以看的网站| 欧美色欧美亚洲另类二区| 国产精品,欧美在线| 亚洲,欧美,日韩| 一本久久中文字幕| 人人妻人人澡欧美一区二区| 老师上课跳d突然被开到最大视频| a级毛片a级免费在线| 亚洲,欧美,日韩| 免费人成视频x8x8入口观看| av在线蜜桃| 亚洲av电影不卡..在线观看| 国产高清视频在线观看网站| 99久久精品一区二区三区| 露出奶头的视频| 日本成人三级电影网站| 亚洲一区高清亚洲精品| 长腿黑丝高跟| 亚洲经典国产精华液单| 中文字幕精品亚洲无线码一区| 日日撸夜夜添| 熟妇人妻久久中文字幕3abv| 亚洲国产精品成人久久小说 | 97热精品久久久久久| 神马国产精品三级电影在线观看| 国产aⅴ精品一区二区三区波| av在线天堂中文字幕| 亚洲中文字幕一区二区三区有码在线看| 精品午夜福利视频在线观看一区| 99在线人妻在线中文字幕| 人妻制服诱惑在线中文字幕| 亚洲人与动物交配视频| av免费在线看不卡| 一个人看视频在线观看www免费| 亚洲欧美中文字幕日韩二区| 久久99热这里只有精品18| 久久久久免费精品人妻一区二区| 亚洲av免费高清在线观看| av国产免费在线观看| 可以在线观看毛片的网站| 欧美xxxx黑人xx丫x性爽| 亚洲自拍偷在线| 国产色婷婷99| 亚洲五月天丁香| 亚洲美女黄片视频| 成人一区二区视频在线观看| 久久天躁狠狠躁夜夜2o2o| 亚洲成人精品中文字幕电影| 免费人成在线观看视频色| 精品久久久久久久末码| 欧美日韩在线观看h| 美女被艹到高潮喷水动态| 亚洲精品久久国产高清桃花| 亚洲精品日韩av片在线观看| 亚洲av中文字字幕乱码综合| 最近手机中文字幕大全| 国产一区二区在线观看日韩| 午夜日韩欧美国产| 男插女下体视频免费在线播放| 精品久久久久久久久亚洲| 精品久久久久久久人妻蜜臀av| 亚洲精品国产av成人精品 | 天堂影院成人在线观看| 69人妻影院| 人人妻,人人澡人人爽秒播| 黄色欧美视频在线观看|